{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:57Z","timestamp":1786653837787,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The study aims to investigate the prognostic significance of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) expression in glottic laryngeal carcinoma (LC) and assess the correlation of their expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>For this study, 40 patients who underwent complete resection of the glottic laryngeal tumor as primary treatment were selected. PD-L1 and TIL expression levels were determined by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Disease-free survival (DFS) was statistically significantly longer in patients with the combined positive score (CPS). CPS \u22651 than those with CPS &lt;1. The concentration of TILs in tumor specimens was not significantly related to gender, age, T status, N status, tumor, node, metastasis (TNM) stage, pathological grade, or locoregional recurrence. Multivariate Cox regression analysis showed that low CPS and positive nodal status are statistically significant and independent predictors of malignancy recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The findings of our study suggest that PD-L1 could be a valuable indicator for predicting recurrence and reduced survival following definitive therapy. Consequently, further comprehensive studies involving larger groups of patients are imperative to ascertain the predictive significance of PD-L1 and TIL as biomarkers in LC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_622_24","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:00:23Z","timestamp":1768831223000},"page":"3-9","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in glottic laryngeal cancer"],"prefix":"10.4103","volume":"69","author":[{"given":"Kadic","family":"Muhedin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Clinical Centre of Montenegro, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvrko","family":"Elvir","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Clinical Centre of Montenegro, Podgorica, Montenegro"},{"name":"Department of Pathology, Clinical Centre of Montenegro, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuckovic","family":"Ljiljana","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical Centre of Montenegro, Podgorica, Montenegro"},{"name":"Faculty of Medicine, University of Montenegro, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catic","family":"Sabina","sequence":"additional","affiliation":[{"name":"Institute for Public Health of Montenegro, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pot","family":"Danilo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Clinical Centre of Montenegro, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"R1-20260403","first-page":"209","article-title":"Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA cancer J Clin"},{"key":"R2-20260403","first-page":"2248","article-title":"Laryngeal cancer:Epidemiology, etiology, and prevention:A narrative review","volume":"52","author":"Igissin","year":"2023","journal-title":"Iran J Public Health"},{"key":"R3-20260403","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/70932","article-title":"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion","volume":"5","author":"Dong","year":"1999","journal-title":"Nat Med"},{"key":"R4-20260403","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-021-00431-4","article-title":"Programmed death ligand 1 signals in cancer cells","volume":"22","author":"Kornepati","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"R5-20260403","doi-asserted-by":"crossref","first-page":"52889","DOI":"10.18632\/oncotarget.17547","article-title":"PD-L1:A novel prognostic biomarker in head and neck squamous cell carcinoma","volume":"8","author":"M\u00fcller","year":"2017","journal-title":"Oncotarget"},{"key":"R6-20260403","doi-asserted-by":"crossref","first-page":"153120","DOI":"10.1016\/j.prp.2020.153120","article-title":"Postoperative radiotherapy for laryngeal cancer. 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