{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:25:42Z","timestamp":1787765142162,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hybrid tumors are rare lesions having features of multiple diseases in one lesion. A hybrid tumor of central giant cell granuloma (CGCG) and central ossifying fibroma (COF) shows the presence of microscopically large areas with CGCG character and large areas with COF features inside a single clinical lesion, separated by a transition zone. A rare type of COF is juvenile ossifying fibroma (JOF)-trabecular variant in the mandible. We present a unique and rare case of a hybrid tumor of the CGCG-JOF-trabecular variant in the mandible of a 14-year-old female which initially diagnosed with CGCG. The ambiguous pathogenesis of hybrid tumors and giant cells is reviewed. The goal of this article is to highlight the importance of careful clinical, radiological, and histopathological examination of each case to prevent misdiagnoses and recurrences. Similar and other cases must be reported in order to better understand the interrelationship between these hybrid lesions and their biological behavior.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_623_22","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T23:03:13Z","timestamp":1705014193000},"page":"638-640","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Hybrid tumor of central giant cell granuloma and trabecular juvenile ossifying fibroma of the mandible: A rare event in the oral cavity with a review on pathogenesis"],"prefix":"10.4103","volume":"67","author":[{"given":"Kundendu Arya","family":"Bishen","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Government College of Dentistry, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Government College of Dentistry, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Rehani","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ajoms.2019.02.007","article-title":"Hybrid central giant cell granuloma and central ossifying fibroma:Case report and literature review","volume":"31","author":"Rai","year":"2019","journal-title":"J Oral Maxillofac Surg Med Pathol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/ams.ams_3_18","article-title":"Juvenile ossifying fibroma in the mandible","volume":"8","author":"Ramaswami","year":"2018","journal-title":"Ann Maxillofac Surg"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"e14236","DOI":"10.1111\/dth.14236","article-title":"Collision tumors:A review of their types, pathogenesis, and diagnostic challenges","volume":"33","author":"Bulte","year":"2020","journal-title":"Dermatol Ther"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.12688\/f1000research.19891.1","article-title":"Case Report:Rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma","volume":"8","author":"Saad","year":"2019","journal-title":"F1000Res"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/mbcb\/2017024","article-title":"Central giant cell granuloma:A case report","volume":"24","author":"Butel","year":"2018","journal-title":"J Oral Med Oral Surg"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4103\/jomfp.jomfp_487_20","article-title":"\u201cCentral giant cell granuloma\u201d- An update","volume":"24","author":"Ramesh","year":"2020","journal-title":"J Oral Maxillofac Pathol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1051\/mbcb\/2017023","article-title":"Juvenile ossifying fibroma:Case report and literature review. Management and differential diagnosis","volume":"24","author":"Lemoine","year":"2018","journal-title":"J Oral Med Oral Surg"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"107082","DOI":"10.1016\/j.ijscr.2022.107082","article-title":"Combined lesion of central giant cell granuloma and ossifying fibroma:A case report of a rare event in oral cavity","volume":"94","author":"Saadaat","year":"2022","journal-title":"Int J Surg Case Rep"},{"key":"R9-20240829","first-page":"954","article-title":"Fibrous dysplasia and central giant cell granuloma:A report of hybrid lesion with its review and hypotheticated pathogenesis","volume":"7","author":"Kurra","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4103\/0973-029X.151310","article-title":"Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma:An immunohistochemical analysis","volume":"18","author":"VK","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s13277-015-3094-y","article-title":"RANK pathway in giant cell tumor of bone:Pathogenesis and therapeutic aspects","volume":"36","author":"Wu","year":"2015","journal-title":"Tumor Biol"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4103\/0973-029X.174631","article-title":"Hybrid lesions comprising central giant cell granuloma and fibrous dysplasia:A diagnostic challenge for pathologist","volume":"19","author":"Jawanda","year":"2015","journal-title":"J Oral Maxillofac Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_623_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:01:44Z","timestamp":1787763704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_623_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_623_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,10]]},"assertion":[{"value":"2022-07-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}