{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:11Z","timestamp":1787071451420,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    IgG4-related disease (\n                    <jats:italic toggle=\"yes\">IgG4-RD<\/jats:italic>\n                    ) is an immune-mediated fibroinflammatory condition with varied clinical manifestations. This case highlights a case of ocular\n                    <jats:italic toggle=\"yes\">IgG4-RD<\/jats:italic>\n                    with systemic involvement. A 41-year-old male patient presented with a painless bulging of the right eye over a 2-year period. Upon examination, there was axial proptosis with mild restriction in ocular motility during right lateral gaze. Investigation revealed elevated serum\n                    <jats:italic toggle=\"yes\">IgG4<\/jats:italic>\n                    levels. Contrast enhanced computed tomography (CECT) showed a well-defined, homogeneously enhancing mass lesion in the right orbit\u2019s intraconal space. Magnetic resonance angiography (MRI) showed hyperintense lesion of size measuring approx. 42 \u00d7 12 \u00d7 26 mm. An ultrasound (USG) guided orbital biopsy revealed lymphoproliferative lesions and abundant\n                    <jats:italic toggle=\"yes\">IgG4<\/jats:italic>\n                    + plasma cells with fibrosis. A fluorodeoxyglucose positive emission tomography (FDG-PET) scan showed a mildly enhancing soft tissue lesion in the right intraconal space. It also revealed abnormal metabolic activity in facial glands, pancreas, and mesenteric lymph nodes (SUV\n                    <jats:sub>max<\/jats:sub>\n                    2.2).\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_631_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T06:00:08Z","timestamp":1766037608000},"page":"114-117","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A case report highlighting the diagnostic modalities for orbital IgG4-related disease with systemic involvement"],"prefix":"10.4103","volume":"69","author":[{"given":"Bhavya","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, GS Medical College, Pilkhuwa, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishaa","family":"Hawaibam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, GS Medical College, Pilkhuwa, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Badgujar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, GS Medical College, Pilkhuwa, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, GS Medical College, Pilkhuwa, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, GS Medical College, Pilkhuwa, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smiti","family":"Juyal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, GS Medical College, Pilkhuwa, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20260403","first-page":"253","article-title":"IgG-4 Related disease: An introduction","volume":"115","author":"Al-Khalili","year":"2018","journal-title":"Mo Med"},{"key":"R2-20260403","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gtc.2019.02.008","article-title":"IgG4-Related disease with emphasis on its gastrointestinal manifestation","volume":"48","author":"Vashi","year":"2019","journal-title":"Gastroenterol Clin North Am"},{"key":"R3-20260403","first-page":"736","article-title":"Maladie \u00e0IgG4: l'exp\u00e9rience genevoise [IgG4 related disease: The Geneva experience","volume":"15","author":"Pellet","year":"2019","journal-title":"Rev Med Suisse"},{"key":"R4-20260403","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","article-title":"Consensus statement on the pathology of IgG4-related disease","volume":"25","author":"Deshpande","year":"2012","journal-title":"Mod Pathol"},{"key":"R5-20260403","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/14397595.2019.1705537","article-title":"IgG4-related disease: How to place it in the spectrum of immune-mediated and rheumatologic disorders?","volume":"30","author":"Borges","year":"2020","journal-title":"Mod Rheumatol"},{"key":"R6-20260403","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/art.39205","article-title":"IgG4-related disease: Clinical and laboratory features in one hundred twenty-five patients","volume":"67","author":"Wallace","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"R7-20260403","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13075-017-1467-x","article-title":"New clues to the nature of immunoglobulin G4-related disease: A retrospective Japanese multicenter study of baseline clinical features of 334 cases","volume":"19","author":"Yamada","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"R8-20260403","first-page":"715","article-title":"[Role of serum IgG4 detection in the diagnosis and treatment of IgG4-related diseases","volume":"21","author":"Zhang","year":"2013","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"R9-20260403","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41584-020-0500-7","article-title":"IgG4-related disease: An update on pathophysiology and implications for clinical care","volume":"16","author":"Perugino","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"R10-20260403","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/acr.22058","article-title":"Usefulness of 2-[18F]-fluoro-2-deoxy-d-glucose\u2013positron emission tomography\/computed tomography for staging and evaluation of treatment response in IgG4-related disease: a retrospective multicenter study","volume":"66","author":"Ebbo","year":"2014","journal-title":"Arthritis Care Res (Hoboken)."},{"key":"R11-20260403","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/14397595.2016.1259602","article-title":"A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease","volume":"27","author":"Masaki","year":"2017","journal-title":"Mod Rheumatol"},{"key":"R12-20260403","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/annrheumdis-2014-206605","article-title":"Rituximab for IgG4-related disease: A prospective, open-label trial","volume":"74","author":"Carruthers","year":"2015","journal-title":"Ann Rheum Dis"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_631_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:19Z","timestamp":1787067979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_631_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_631_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"2025-06-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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