{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:31:02Z","timestamp":1786739462813,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Melanomas within the Central Nervous System (CNS) are most commonly metastatic lesions, with primary melanomas comprising only 0.05\u20130.07% of all brain tumors. We report three cases of primary CNS melanoma. The patients were young adults. There were two females and one male. On preoperative investigations, two cases were misdiagnosed to be angiomas on Magnetic Resonance Imaging (MRI). The melanotic nature of the lesion was an intraoperative observation. Pathologic examination showed features of malignancy with invasion of tumor cells into the brain parenchyma. In two patients, presence of systemic lesions were ruled out after surgery by whole-body Positron Emission Tomography (PET) scan. These patients were subject to adjuvant radiotherapy, while one patient succumbed immediately post-surgery. Primary CNS melanomas are rare with no defined treatment protocols. Histopathology diagnosis is crucial to rule out pigmented mimics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_642_20","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:47:34Z","timestamp":1627555654000},"page":"535-540","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Melanoma of the central nervous system"],"prefix":"10.4103","volume":"64","author":[{"given":"Pooja K.","family":"Gajaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha S.","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naina A.","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20240829","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejcsup.2013.07.012","article-title":"Melanoma epidemiology, biology and prognosis","volume":"11","author":"Ali","year":"2013","journal-title":"EJC Suppl"},{"key":"R2-18-20240829","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10143-017-0914-0","article-title":"Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: A case report and review of the literature","volume":"41","author":"Fujimori","year":"2018","journal-title":"Neurosurg Rev"},{"key":"R3-18-20240829","first-page":"1","article-title":"Primary intracranial melanoma with early leptomeningeal spread: A case report and treatment options available","volume":"2015","author":"Balakrishnan","year":"2015","journal-title":"Case Rep Oncol Med"},{"key":"R5-18-20240829","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jcp.21935","article-title":"Melanocytes in development and cancer","volume":"222","author":"Uong","year":"2010","journal-title":"J Cell Physiol"},{"key":"R6-18-20240829","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/2152-7806.111296","article-title":"Epidemiology and prognosis of brain metastases","volume":"4","author":"Stelzer","year":"2013","journal-title":"Surg Neurol Int"},{"key":"R7-18-20240829","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1200\/JOP.2016.011882","article-title":"Management of brain metastases in patients with melanoma","volume":"12","author":"Chukwueke","year":"2016","journal-title":"J Oncol Pract"},{"key":"R8-18-20240829","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/jnnp.39.6.526","article-title":"Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings","volume":"39","author":"Hayward","year":"1976","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R9-18-20240829","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/1793-5482.151508","article-title":"Primary intracranial malignant melanoma: A rare case with review of literature","volume":"10","author":"Suranagi","year":"2015","journal-title":"Asian J Neurosurg"},{"key":"R10-18-20240829","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3892\/ol.2015.3537","article-title":"Intracranial malignant melanoma: A report of 7 cases","volume":"10","author":"Ma","year":"2015","journal-title":"Oncol Lett"},{"key":"R11-18-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12957-015-0600-z","article-title":"Intracranial amelanotic melanoma: A case report with literature review","volume":"13","author":"Ma","year":"2015","journal-title":"World J Surg Oncol"},{"key":"R12-18-20240829","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3340\/jkns.2015.58.6.554","article-title":"Primary intracranial leptomeningeal melanomatosis","volume":"58","author":"Kim","year":"2015","journal-title":"J Korean Neurosurg Soc"},{"key":"R13-18-20240829","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/0028-3886.173657","article-title":"Black brain caused by primary intracranial malignant melanoma","volume":"64","author":"Naik","year":"2016","journal-title":"Neurol India"},{"key":"R14-18-20240829","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.wneu.2016.06.039","article-title":"Primary amelanotic leptomeningeal melanomatosis in a child: A rare but severe disease","volume":"92","author":"Szathmari","year":"2016","journal-title":"World Neurosurg"},{"key":"R15-18-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-016-2556-y","article-title":"NRASQ61K mutated primary leptomeningeal melanoma in a child: Case presentation and discussion on clinical and diagnostic implications","volume":"16","author":"Angelino","year":"2016","journal-title":"BMC Cancer"},{"key":"R16-18-20240829","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3340\/jkns.2015.0506.007","article-title":"Primary intracranial malignant melanoma with extracranial metastasis","volume":"60","author":"Hirota","year":"2017","journal-title":"J Korean Neurosurg Soc"},{"key":"R17-18-20240829","first-page":"1","article-title":"Primary cerebral malignant melanoma: A case report with literature review","volume":"96","author":"Tang","year":"2017","journal-title":"Medicine"},{"key":"R18-18-20240829","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/1793-5482.224832","article-title":"A Unique case of primary intracranial melanoma","volume":"13","author":"Sarmast","year":"2018","journal-title":"Asian J Neurosurg"},{"key":"R19-18-20240829","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/s-0037-1604326","article-title":"Primary amelanotic CNS melanoma: Case report and literature review","volume":"79","author":"Mayer","year":"2018","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"R20-18-20240829","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1148\/rg.295095109","article-title":"Pigmented lesions of the central nervous system: Radiologic-pathologic correlation","volume":"29","author":"Smith","year":"2009","journal-title":"Radiographics"},{"key":"R21-18-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2016.00059","article-title":"Gnaq and Gna11 in the endothelin signaling pathway and melanoma","volume":"7","author":"Urtatiz","year":"2016","journal-title":"Front Genet"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_642_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:29:09Z","timestamp":1786735749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_642_20"}},"subtitle":["A report of three cases"],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_642_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}