{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:25:55Z","timestamp":1783416355637,"version":"3.54.6"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prostate cancer is the second most common cancer in men, with bone metastases in advanced cases, commonly involving the spine. Pleomorphic giant cell carcinoma (PGCC) is a rare and aggressive variant of prostate cancer. We present a 71-year-old male with a history of prostate adenocarcinoma, treated with prostatectomy, radiotherapy and androgen blockade, who developed progressive lower back pain and bilateral leg weakness. Imaging showed spinal metastases at L5\u2013S1 and D6\u2013D7, with spinal cord compression. Biopsy revealed a metastatic high-grade, poorly differentiated tumor, consistent with PGCC. The patient received palliative radiotherapy and supportive care. This case underscores the confounding morphology and aggressive nature of PGCC, and the need for tailored management in metastatic prostate cancer.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_658_25","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:54:55Z","timestamp":1782852895000},"page":"377-380","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The shape-shifter: A case of pleomorphic giant cell carcinoma of prostate"],"prefix":"10.4103","volume":"69","author":[{"given":"Seema","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Histopathology, Sir Gangaram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Ali","family":"Osama","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunayana","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Sir Gangaram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satnam S.","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sir Gangaram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KL","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Sir Gangaram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"R1-20260707","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1158\/1078-0432.CCR-10-3120","article-title":"Characterization of bone metastases from rapid autopsies of prostate cancer patients","volume":"17","author":"Mehra","year":"2011","journal-title":"Clin Cancer Res"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00428-022-03481-7","article-title":"Pleomorphic giant cell carcinoma of the prostate: Clinicopathologic analysis and oncological outcomes","volume":"482","author":"Bil\u00e9-Silva","year":"2023","journal-title":"Virchows Arch"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"151719","DOI":"10.1016\/j.anndiagpath.2021.151719","article-title":"Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features","volume":"52","author":"El-Zaatari","year":"2021","journal-title":"Ann Diagn Pathol"},{"key":"R4-20260707","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.annonc.2020.02.002","article-title":"Epigenetic modulations and lineage plasticity in advanced prostate cancer","volume":"31","author":"Ge","year":"2020","journal-title":"Ann Oncol"},{"key":"R5-20260707","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00428-022-03481-7","article-title":"Pleomorphic giant cell carcinoma of the prostate: clinicopathologic analysis and oncological outcomes","volume":"482","author":"Bil\u00e9-Silva","year":"2023","journal-title":"Virchows Arch"},{"key":"R6-20260707","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1158\/2159-8290.CD-17-0867","article-title":"Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with pten loss to accelerate progression and castration-resistant growth","volume":"8","author":"Pearson","year":"2018","journal-title":"Cancer Discov"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijpm.ijpm_658_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:02:30Z","timestamp":1783414950000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/ijpm.ijpm_658_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_658_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-07-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}