{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:32:01Z","timestamp":1787841121192,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Granulomatous hypophysitis is a rare form of pituitary inflammation that closely mimics pituitary macroadenoma in clinical presentation as well as radiological appearance. Histopathology remains the gold standard diagnostic modality. Here, we present the case of a young female who presented with symptoms of anterior and posterior pituitary dysfunction, including secondary amenorrhea, cold intolerance, polyuria, and polydipsia. Magnetic resonance imaging revealed a sellar mass with suprasellar extension, suggesting a pituitary macroadenoma. Histopathological examination of the transsphenoidal biopsy revealed granulomatous hypophysitis. Extensive systemic workup of the patient did not identify any secondary infectious or autoimmune etiological conditions. She was treated with corticosteroids, thyroxine, and desmopressin. This case emphasizes the importance of considering hypophysitis as a differential diagnosis of common sellar lesions like pituitary macroadenoma and highlights the role of histopathological examination in definitive diagnosis and to determine the appropriate course of management.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_660_25","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:00:08Z","timestamp":1768831208000},"page":"156-158","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Rare case of primary granulomatous hypophysitis mimicking pituitary macroadenoma: A diagnostic challenge"],"prefix":"10.4103","volume":"69","author":[{"given":"Ankita","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pathology, Command Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessy","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pathology, Command Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Command Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav P. S.","family":"Gahlot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Command Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"R1-20260403","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.3390\/ijms24065917","article-title":"Hypophysitis: Defining histopathologic variants and a review of emerging clinical causative entities","volume":"24","author":"Rawanduzy","year":"2023","journal-title":"Int J Mol Sci"},{"key":"R2-20260403","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12883-023-03060-6","article-title":"A case of pituitary gland abscess associated with granulomatous hypophysitis","volume":"23","author":"Rabiei","year":"2023","journal-title":"BMC Neurol"},{"key":"R3-20260403","doi-asserted-by":"crossref","first-page":"17562864231182519","DOI":"10.1177\/17562864231182519","article-title":"Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis","volume":"16","author":"Chen","year":"2023","journal-title":"Ther Adv Chronic Dis"},{"key":"R4-20260403","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/clinem\/dgab672","article-title":"Hypophysitis, the growing spectrum of a rare pituitary disease","volume":"107","author":"Langlois","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"R5-20260403","first-page":"13","article-title":"A trial of oral glucocorticoids in the resolution of recurrent granulomatous hypophysitis: A case report","volume":"34","author":"Rodriguez-Asuncionk","year":"2023","journal-title":"J ASEAN Fed Endocr Soc"},{"key":"R6-20260403","first-page":"1","article-title":"Primary granulomatous hypophysitis with panhypopituitarism, presenting as aseptic meningitis in a 14-year-old boy","volume":"95","author":"Stern","year":"2022","journal-title":"Horm Res Paediatr"},{"key":"R7-20260403","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14791\/btrt.2019.7.e22","article-title":"Idiopathic granulomatous hypophysitis with rapid onset: A case report","volume":"7","author":"Park","year":"2019","journal-title":"Brain Tumor Res Treat"},{"key":"R8-20260403","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5603\/EP.a2019.0015","article-title":"Hypophysitis-new insights into diagnosis and treatment","volume":"70","author":"Kluczy\u0144ski","year":"2019","journal-title":"Endokrynol Pol"},{"key":"R9-20260403","doi-asserted-by":"crossref","first-page":"104076","DOI":"10.1016\/j.lpm.2021.104076","article-title":"Hypophysitis: A comprehensive overview","volume":"50","author":"de","year":"2021","journal-title":"Presse Med"},{"key":"R10-20260403","doi-asserted-by":"crossref","first-page":"16","DOI":"10.14341\/probl12777","article-title":"Clinical and radiological diagnosis of hypophysitis: A review of literature and own data","volume":"68","author":"Voronstov","year":"2022","journal-title":"Prob Endocrinol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_660_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:42:47Z","timestamp":1787838167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_660_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_660_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}