{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:30:18Z","timestamp":1786739418408,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Sertoli-Leydig Cell Tumors (SLCT) are very rare neoplasms of the ovary (0.2%) and they belong to the group of sex cord-stromal tumors. Of these, 20% of the cases show heterologous elements. We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resembling carcinoid were also noted. Immunohistochemistry was performed and the Sertoli-Leydig Cells were positive for CD56, calretinin, inhibin, vimentin, and ER. The glandular component was positive for CK20, EMA, CEA, and CDX2. Synaptophysin and chromogranin were positive within nests resembling carcinoid. With the given histomorphological features and immunohistochemistry findings, a diagnosis of moderately differentiated Sertoli-Leydig Cell Tumor of the ovary with associated mucinous carcinoma and carcinoid was rendered. The presence of heterologous elements in SLCTs has been reported to be associated with poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_672_20","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:47:34Z","timestamp":1627555654000},"page":"528-531","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid\u2014A case report and review of literature"],"prefix":"10.4103","volume":"64","author":[{"given":"Aarthiprabha","family":"Ravichandaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Lakshmanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Kurian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikala","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-16-20240829","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00000478-198508000-00001","article-title":"Ovarian sertoli-leydig cell tumors. 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Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein","volume":"8","author":"Young","year":"1984","journal-title":"Am J Surg Pathol"},{"key":"R5-16-20240829","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1002\/1097-0142(19821201)50:11<2448::AID-CNCR2820501133>3.0.CO;2-T","article-title":"Ovarian Sertoli-Leydig cell tumors with heterologous elements. I. Gastrointestinal epithelium and carcinoid: A clinicopathologic analysis of thirty-six cases","volume":"50","author":"Young","year":"1982","journal-title":"Cancer"},{"key":"R6-16-20240829","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/1097-0142(19821201)50:11<2465::AID-CNCR2820501135>3.0.CO;2-U","article-title":"Ovarian Sertoli-Leydig cell tumors with heterologous elements. II. Cartilage and skeletal muscle: A clinicopathologic analysis of twelve cases","volume":"50","author":"Prat","year":"1982","journal-title":"Cancer"},{"key":"R7-16-20240829","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0046-8177(99)90083-7","article-title":"Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: Distinguishing a heterologous element from Leydig cells","volume":"30","author":"Mooney","year":"1999","journal-title":"Hum Pathol"},{"key":"R8-16-20240829","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/1097-0142(19871215)60:12<3056::AID-CNCR2820601233>3.0.CO;2-R","article-title":"Ovarian Sertoli-Leydig cell tumor (androblastoma) with retiform pattern. A clinicopathologic study","volume":"60","author":"Talerman","year":"1987","journal-title":"Cancer"},{"key":"R9-16-20240829","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/00000478-199906000-00001","article-title":"Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: Atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas","volume":"23","author":"Riopel","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"R10-16-20240829","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/1097-0142(20001001)89:7<1541::AID-CNCR18>3.0.CO;2-9","article-title":"Noninvasive, microinvasive, and invasive mucinous carcinomas of the ovary: A clinicopathologic analysis of 40 cases","volume":"89","author":"Nomura","year":"2000","journal-title":"Cancer"},{"key":"R11-16-20240829","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ygyno.2017.09.034","article-title":"DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International ovarian and testicular stromal tumor registry","volume":"147","author":"Schultz","year":"2017","journal-title":"Gynecol Oncol"},{"key":"R12-16-20240829","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1097\/PAS.0000000000000895","article-title":"DICER1 mutations are consistently present in moderately and poorly differentiated Sertoli-Leydig cell tumors","volume":"41","author":"de Kock","year":"2017","journal-title":"Am J Surg Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_672_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:28:49Z","timestamp":1786735729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_672_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_672_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}