{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:26:35Z","timestamp":1787765195102,"version":"build-2784847793"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Autoimmune liver diseases (AILD) represent a spectrum of related yet distinct immune-mediated disorders. The literature on the prevalence of these AILDs in Indian population is scarce. This study aims to assess the prevalence and clinicopathological spectrum of various AILDs especially the overlap syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A 10-year (2011\u20132020) cross-sectional, retrospective observational study of histological proven cases of AILD was conducted. Clinical, demographic, and laboratory parameters were retrieved. Two pathologists independently reviewed the liver biopsies and reassessed 18 histopathological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      During the study period, 17664 liver biopsies were received, out of which 1060 (6%) biopsies of AILD were identified. After exclusion, we had 721 cases which revealed a distribution of autoimmune hepatitis (AIH)-64.7%, primary biliary cholangitis (PBC)-14.8%, primary sclerosing cholangitis (PSC)-7.6%, overlap AIH-PBC 11%, and overlap AIH-PSC 1.7%. AIH patients had significantly higher prevalence for severe lobular inflammation (27%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), several lobular plasma cells (37%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), central perivenulitis (30%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), hepatic rosettes (51%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), and necrosis (35.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), while PBC patients had significantly higher frequency of florid duct lesions (11.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), duct loss (83.17%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), bile duct damage (76.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), and periportal copper deposits (19.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001). Overlap AIH-PBC group had the highest proportion of severe portal inflammation (27.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), prominent portal plasma cells (75%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), moderate interface activity (53.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), Mallory-Denk bodies (27.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), and periportal cholate stasis (25%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prevalence of biopsy-proven AILDs in our study cohort is 6%. AIH (64.7%) is the most common AILD followed by PBC (14.8%). Overlap syndrome (AIH-PBC) showed prevalence of 11%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_72_22","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T04:39:07Z","timestamp":1705639147000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and clinicopathological Spectrum of Auto-Immune Liver Diseases &amp; Overlap syndrome"],"prefix":"10.4103","volume":"67","author":[{"given":"Annapoorani","family":"Varadarajan","sequence":"first","affiliation":[{"name":"Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherin","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saggere Muralikrishna","family":"Shasthry","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/hep.1840180435","article-title":"Meeting report:International autoimmune hepatitis group","volume":"18","author":"Johnson","year":"1993","journal-title":"Hepatology"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International autoimmune hepatitis group report:Review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"Simplified criteria for the 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