{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:14Z","timestamp":1786728494383,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nipple adenoma (NA) is a rare benign neoplasm of the nipple arising from the lactiferous duct. Often seen in middle aged women, presenting as a nodule, erosive, or ulcerative lesion and associated with serous or bloody discharge. Histologically, they comprise closely arranged tubules with papillary infoldings centered around the lactiferous ducts. It is most likely clinically confused with Paget\u2019s disease and histologically with invasive breast carcinoma or its precursor lesions. The aid of immunohistochemistry is valuable in differentiating these entities and to definitively exclude malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>All cases with available slides and blocks, diagnosed as nipple adenoma, during the period of January 2015 to December 2021, will be identified through an appropriate query search from the pathology database. Clinico-radiological details and histopathology will be studied and analyzed. The available follow up data and clinical outcome will be assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixteen cases of nipple adenoma were studied and the median age at diagnosis was found to be 37 years. Nipple discharge and swelling were the most common presentations. Ultrasound imaging was done in 14 cases with the median size of lesion being 0.8cms. Seven underwent excision biopsy followed by histopathological examination. The most common histological pattern observed is \u201cadenosis\u201d pattern. Immunostains p63, smooth muscle myosin heavy chain (SMMHC) and CK5\/6 were performed. Nine cases were on follow up but none had recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NA is a benign entity with varied histological patterns. Histopathological examination with the aid of immunohistochemistry helps in diagnosis and to rule out other mimickers. Surgical excision is the treatment of choice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_742_23","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:12:08Z","timestamp":1723461128000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Nipple adenoma: A clinicopathological study over a period of six years in tertiary care center"],"prefix":"10.4103","volume":"68","author":[{"given":"H S Fathima","family":"Afshan","sequence":"first","affiliation":[{"name":"Department of General Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Nirmal","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Santhosh","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elanthenral","family":"Sigamani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"R1-20250411","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12895-016-0041-6","article-title":"Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin:Case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin","volume":"16","author":"Spohn","year":"2016","journal-title":"BMC Dermatol"},{"key":"R2-20250411","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/1097-0142(1955)8:2<315::AID-CNCR2820080211>3.0.CO;2-8","article-title":"Florid papillomatosis of the nipple ducts","volume":"8","author":"Jones","year":"1955","journal-title":"Cancer"},{"key":"R3-20250411","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1002\/ccr3.3398","article-title":"Dermoscopy of nipple adenoma","volume":"8","author":"Ansari","year":"2020","journal-title":"Clin Case Rep"},{"key":"R4-20250411","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1746-1596-7-162","article-title":"Nipple adenoma arising from axillary accessory breast:A case report","volume":"7","author":"Shioi","year":"2012","journal-title":"Diagn Pathol"},{"key":"R6-20250411","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.3892\/ol.2014.2000","article-title":"Adenoma of the nipple:A clinicopathological report of 13 cases","volume":"7","author":"Di","year":"2014","journal-title":"Oncol Lett"},{"key":"R7-20250411","doi-asserted-by":"crossref","first-page":"29","DOI":"10.21037\/abs.2019.10.03","article-title":"Nipple adenoma:A review of the literature","volume":"3","author":"Tatterton","year":"2019","journal-title":"Ann Breast Surg"},{"key":"R8-20250411","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.path.2009.02.010","article-title":"Lesions of the nipple","volume":"2","author":"Dillon","year":"2009","journal-title":"Surg Pathol Clin"},{"key":"R10-20250411","first-page":"573","article-title":"The usefulness of p63 as a marker of breast myoepithelial cells","volume":"17","author":"Batistatou","year":"2003","journal-title":"Vivo Athens Greece"},{"key":"R11-20250411","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/jcp.2006.036830","article-title":"The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast","volume":"60","author":"Tse","year":"2007","journal-title":"J Clin Pathol"},{"key":"R12-20250411","doi-asserted-by":"crossref","first-page":"422","DOI":"10.5858\/2010-0336-CP.1","article-title":"Best practices in diagnostic immunohistochemistry:Myoepithelial markers in breast pathology","volume":"135","author":"Dewar","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"R13-20250411","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/1346-8138.13237","article-title":"5-Hydroxymethylcytosine as a putative marker for erosive adenomatosis of the nipple","volume":"43","author":"Takazawa","year":"2016","journal-title":"J Dermatol"},{"key":"R14-20250411","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/his.13043","article-title":"Frequent PIK3CA activating mutations in nipple adenomas","volume":"70","author":"Liau","year":"2017","journal-title":"Histopathology"},{"key":"R15-20250411","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/ans.12744","article-title":"Diagnosis and surgical treatment of nipple adenoma","volume":"85","author":"Wang","year":"2015","journal-title":"ANZ J Surg"},{"key":"R16-20250411","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00000478-198602000-00002","article-title":"Florid papillomatosis of the nipple. A study of 51 patients, including nine with mammary carcinoma","volume":"10","author":"Rosen","year":"1986","journal-title":"Am J Surg Pathol"},{"key":"R17-20250411","first-page":"e8586","article-title":"Invasive breast carcinoma arising in a nipple adenoma after 15 years:Report of a rare case and literature review","volume":"12","author":"Abdulwaasey","year":"2020","journal-title":"Cureus"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_742_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:47Z","timestamp":1786724867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_742_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_742_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"2023-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}