{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:44Z","timestamp":1786728524697,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Amyloid fibrils aggregate and deposit in many tissues and multiple organs, leading to systemic amyloidosis. One of the main forms of systemic amyloidosis is called amyloid A (AA) amyloidosis, where chronic inflammation causes the serum amyloid A (SAA) protein to transform into a precursor protein. Regarding the etiology of AA amyloidosis, it was noted that inflammatory arthritis, such as rheumatoid arthritis, was the most common underlying pathology and that malignant disease was one of the uncommon causes. Amongst the malignant causes, the common carcinomatous etiology of amyloidosis has been identified as renal cell carcinoma (RCC). We report a case of incidental detection of ipsilateral renal and adrenal gland AA amyloidosis with RCC in a patient who died 10 days after surgery due to sepsis and multiorgan failure. A 65-year-old female who presented with weight loss, haematuria, left loin pain, severe fatigue, anemia, and facial puffiness for 4 weeks before admission. An ultrasonography (USG) of the abdomen and pelvis revealed a well-encapsulated mass lesion involving the anteromedial aspect of the upper pole of the left kidney, with the possibility of a malignant mass lesion. On histopathology, it was a clear cell RCC with adjacent renal parenchyma and adrenal gland showing amyloid deposits, which showed apple green birefringence on the polariser. These deposits were positive for serum amyloid A on immunohistochemistry (IHC). Thus, renal cell carcinoma, amongst solid organ malignancies, can be the most common cause of systemic amyloidosis.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_76_25","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:01:55Z","timestamp":1769065315000},"page":"306-308","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["An intriguing case report of coincidental occurrence of Amyloid A amyloidosis with renal cell carcinoma in the ipsilateral kidney and adrenal gland"],"prefix":"10.4103","volume":"69","author":[{"given":"Agarwal","family":"Khushbu","sequence":"first","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre - Institute of Transplantation Sciences, Gujarat University of Transplantation Sciences, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paghadar","family":"Komal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre - Institute of Transplantation Sciences, Gujarat University of Transplantation Sciences, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanodia","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre - Institute of Transplantation Sciences, Gujarat University of Transplantation Sciences, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthar","family":"Kamlesh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre - Institute of Transplantation Sciences, Gujarat University of Transplantation Sciences, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"R1-20260707","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/CLEP.S39981","article-title":"Systemic AA amyloidosis: Epidemiology, diagnosis, and management","volume":"6","author":"Real","year":"2014","journal-title":"Clin Epidemiol"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"958","DOI":"10.7326\/0003-4819-55-6-958","article-title":"Amyloidosis in association with neoplastic disease. Report of an unusual case and clinicopathological experience at memorial center for cancer and allied diseases during eleven years (1948-1958)","volume":"55","author":"Kimball","year":"1961","journal-title":"Ann Intern Med"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMoa070265","article-title":"Natural history and outcome in systemic AA amyloidosis","volume":"356","author":"Lachmann","year":"2007","journal-title":"N Engl J Med"},{"key":"R4-20260707","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.0954-6820.1940.tb09080.x","article-title":"On amyloidosis induced by tumors of the kidney","volume":"104","author":"Ask-Upmark","year":"1940","journal-title":"Acta Med Scand"},{"key":"R5-20260707","first-page":"411","article-title":"Systemic amyloidosis and non-hematologic malignancy in a large autopsy series","volume":"89","author":"Dictor","year":"1981","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"R6-20260707","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/jcp.19.6.539","article-title":"Systemic amyloidosis and malignant disease","volume":"19","author":"Azzopardi","year":"1966","journal-title":"J Clin Pathol"},{"key":"R7-20260707","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/ndt\/gfac217","article-title":"AA amyloidosis associated with cancers","volume":"38","author":"Bharati","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"R8-20260707","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0046-8177(83)80016-1","article-title":"Renal cell carcinoma and systemic amyloidosis: Demonstration of AA protein and review of the literature","volume":"14","author":"Vanatta","year":"1983","journal-title":"Hum Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_76_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:28:12Z","timestamp":1786724892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_76_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_76_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-01-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}