{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:05Z","timestamp":1786728485350,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Staphylococcal scalded skin syndrome (SSSS), also known as Ritter\u2019s disease, in its severe form occurs predominantly in infants and children. It is caused by infection with group II (often phage group 71)\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    . The foci of infection include nasopharynx, less commonly umbilicus, urinary tract, superficial abrasion, conjunctivae, and blood.\n                    <jats:italic toggle=\"yes\">Staphylococci<\/jats:italic>\n                    are non-motile, non-spore-forming, catalase-positive, gram-positive cocci that appear predominantly as grape-like clusters. Although this organism is frequently a part of normal human microbial flora, it can cause significant opportunistic infections under certain conditions such as when extremes of age groups are involved, the presence of indwelling medical devices, and intravenous (iv) drug abuse.\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    may cause a variety of infectious manifestations ranging from relatively benign skin infections to life-threatening systemic illnesses. SSSS caused by\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    strains produces exfoliative toxins which result in the development of blisters, erythema, and desquamation. Here, we present a case of an 11-day-old neonate who was diagnosed with SSSS. The causative agent responsible for this syndrome was identified as methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA). The molecular characterization of the gene Panton-Valentine leukocidin (PVL) was done by polymerase chain reaction (PCR) and was detected positive for PVL which is a distinctive virulence factor seen almost in all of the community-acquired MRSA strains. The patient was discharged after parenteral clindamycin therapy with almost complete resolution of symptoms.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_833_23","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:01:12Z","timestamp":1708495272000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Staphylococcal scalded skin syndrome in neonate: Another face of CA-MRSA"],"prefix":"10.4103","volume":"68","author":[{"given":"M Mohamadiya","family":"Rizwana","sequence":"first","affiliation":[{"name":"Department of Microbiology, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shanmugapriya","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Jaya","family":"Sudha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Appalaraju","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"R1-20250411","article-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2023","journal-title":"CLSI supplement M100. Clinical and Laboratory Standards Institute"},{"key":"R2-20250411","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/toxins13100677","article-title":"Staphylococcus aureus Toxins:An Update on Their Pathogenic Properties and Potential Treatments","volume":"13","author":"Ahmad-Mansour","year":"2021","journal-title":"Toxins (Basel)"},{"key":"R3-20250411","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1128\/JCM.39.6.2050-2054.2001","article-title":"Development and evaluation of detection systems for staphylococcal exfoliative toxin A responsible for the scalded-skin syndrome","volume":"39","author":"Ladhani","year":"2001","journal-title":"J Clin Microbiol"},{"key":"R4-20250411","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1172\/JCI20480","article-title":"Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome","volume":"114","author":"Nagasaka","year":"2004","journal-title":"J Clin 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History"}},{"value":"2023-12-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}