{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:48Z","timestamp":1786649388871,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lipoblastomas are benign tumors arising from embryonic white fatty cells that continue to proliferate and develop during the postnatal period. It commonly affects children 3 years of age or younger, with the neck being the most frequent site in the head and neck region. Only 10% of cases are seen at 10 years or above. The etiopathogenesis of lipoblastomas is linked to polysomy and rearrangement of chromosome 8q11\u201313 with or without the involvement of the pleomorphic adenoma gene 1 (PLAG1) gene. Here, we report one of the first cases of lipoblastoma of lip in a 10-year-old boy with atypical immunohistochemical features and the need for thorough clinical and histopathological evaluation of cases with atypical findings. The novel pathogenetic mechanism of lipoblastoma from the cluster of differentiation 34-positive (CD34+) stem cells has also been discussed.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_841_23","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:01:13Z","timestamp":1708495273000},"page":"204-207","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Lipoblastoma of the lip"],"prefix":"10.4103","volume":"68","author":[{"given":"Jochima","family":"Cota","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa R.","family":"Borkar","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Goa Dental College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitisha J.","family":"Savalkar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chalakkal","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Goa Dental College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Spadigam","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"R1-20250411","doi-asserted-by":"crossref","first-page":"153591","DOI":"10.1016\/j.prp.2021.153591","article-title":"The 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novel PLAG1 fusion partners","volume":"34","author":"Fritchie","year":"2021","journal-title":"Mod Pathol"},{"key":"R5-20250411","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13104-018-3153-8","article-title":"Lipoblastoma:A clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature","volume":"11","author":"Abdul-Ghafar","year":"2018","journal-title":"BMC Res Notes"},{"key":"R6-20250411","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s12105-023-01575-5","article-title":"Lipoblastoma arising in the head and neck:A clinicopathologic analysis of 20 cases","volume":"17","author":"Aldawood","year":"2023","journal-title":"Head Neck Pathol"},{"key":"R7-20250411","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.bjps.2011.05.028","article-title":"Lipoblastomatosis appearing as an unusual symmetric upper lip deformity","volume":"64","author":"Morioka","year":"2011","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"R8-20250411","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.humpath.2020.07.016","article-title":"New molecular insights into the pathogenesis of lipoblastomas:Clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases","volume":"104","author":"Lopez-Nunez","year":"2020","journal-title":"Hum Pathol"},{"key":"R9-20250411","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/pin.12077","article-title":"Desmin-positivity in spindle cells:Under-recognized immunophenotype of lipoblastoma","volume":"63","author":"Kubota","year":"2013","journal-title":"Pathol Int"},{"key":"R10-20250411","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1346-8138.2004.tb00610.x","article-title":"Coexistence of spindle cell lipoma and ordinary lipoma","volume":"31","author":"Sakai","year":"2004","journal-title":"J Dermatol"}],"container-title":["Indian Journal of Pathology and 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