{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:10:36Z","timestamp":1789499436388,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chromophobe renal cell carcinoma (CRCC) is a distinct subtype of renal cell carcinoma with unique histological, immunohistochemical, cytogenetic, and ultrastructural features, which usually has a favorable clinical course, with only a small percentage of patients developing recurrence, metastasis, or death due to its complications. Sarcomatoid differentiation can occur in any subtype of renal cell carcinoma and currently represents the transformation into a higher degree of malignancy, its presence being associated with a reserved prognosis, with a reported incidence of average survival of less than 1 year after diagnosis. In this study, we present an unusual case of CRCC with massive sarcomatoid differentiation, which infiltrated the left adrenal gland and was surgically resected. The histological features of this tumor as well as a brief review of literature are presented.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_85_22","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T02:40:09Z","timestamp":1717036809000},"page":"839-841","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Chromophobe renal cell carcinoma with massive sarcomatoid differentiation"],"prefix":"10.4103","volume":"66","author":[{"given":"Anca-Iulia","family":"Neagu","sequence":"first","affiliation":[{"name":"Dunarea de Jos University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Neagu","sequence":"additional","affiliation":[{"name":"Dunarea de Jos University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Anca","family":"Stefanopol","sequence":"additional","affiliation":[{"name":"Dunarea de Jos University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel","family":"Nechita","sequence":"additional","affiliation":[{"name":"Dunarea de Jos University of Galati, Faculty of Medicine and Pharmacy, Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02890129","article-title":"Human chromophobe cell renal carcinoma","volume":"48","author":"Thoenes","year":"1985","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.eururo.2018.01.005","article-title":"Predicting oncologic outcomes in renal cell carcinoma after surgery","volume":"73","author":"Leibovich","year":"2018","journal-title":"Eur Urol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00000478-200305000-00005","article-title":"Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma","volume":"27","author":"Cheville","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1200\/JCO.2002.11.123","article-title":"Treatment outcome and survival associated with metastatic renal cell carcinoma of nonclear-cell histology","volume":"20","author":"Motzer","year":"2002","journal-title":"J Clin Oncol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1097\/PAS.0b013e3181e96f2a","article-title":"A novel tumor grading scheme for chromophobe renal cell carcinoma: Prognostic utility and comparison with Fuhrman nuclear grade","volume":"34","author":"Paner","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00428-019-02710-w","article-title":"Multi-institutional reevaluation of prognostic factors in chromophobe renal cell carcinoma: Proposal of a novel two-tiered grading scheme","volume":"476","author":"Ohashi","year":"2020","journal-title":"Virchows Arch"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1309\/VLV6-BRTR-HY5B-H485","article-title":"Comparison of standardized and nonstandardized nuclear grade of renal cell carcinoma to predict outcome among 2,042 patients","volume":"118","author":"Lohse","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.5858\/133.11.1857","article-title":"Sarcomatoid chromophobe renal cell carcinoma with heterologous sarcomatoid elements. A case report and review of the literature","volume":"133","author":"Quiroga-Garza","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/modpathol.3800739","article-title":"Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma","volume":"20","author":"Brunelli","year":"2007","journal-title":"Mod Pathol"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1093\/annonc\/mdu445","article-title":"PD-L1 expression in nonclear-cell renal cell carcinoma","volume":"25","author":"Choueiri","year":"2014","journal-title":"Ann Oncol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_85_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:32:40Z","timestamp":1787067160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_85_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_85_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]},"assertion":[{"value":"2022-01-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}