{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:28Z","timestamp":1787169868119,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute leukemias often show simultaneous expression of multiple lineage antigens and pose diagnostic challenges to classify them. Strict adherence to WHO criteria is essential to classify leukemias as mixed phenotype acute leukemia or leukemias of a specific lineage with aberrant expression of cross lineage antigen. Here, we present three cases of acute leukemias with co-expression of B- and T-lymphoid markers and a comprehensive use of flowcytometric immunophenotyping and immunohistochemistry to reach a correct diagnosis. However, clinically, all 3 cases presented similarly, with lymphadenopathy. We attempt to highlight the overlapping clinical presentation and immunophenotypic profile, and emphasize the need for careful use of multiple modalities before rendering a diagnosis.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_862_25","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:00:17Z","timestamp":1771592417000},"page":"313-318","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Acute Leukemias with Simultaneous Expression of B- and T-Lymphoid Markers\u2014A Comprehensive Diagnostic Approach for Immunophenotypic characterization"],"prefix":"10.4103","volume":"69","author":[{"given":"Debdeep","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sada","family":"Mounika","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhajit","family":"Hajra","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pronati","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Department of Laboratory Services, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basab","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Department of Laboratory Services, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"R1-20260707","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: Myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"R2-20260707","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: Lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3324\/haematol.2012.064485","article-title":"Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult 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mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations","volume":"93","author":"Mi","year":"2018","journal-title":"Am J Hematol"},{"key":"R7-20260707","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1182\/bloodadvances.2021004334","article-title":"Genomic and clinical characterization of early T-cell precursor lymphoblastic lymphoma","volume":"5","author":"Xu","year":"2021","journal-title":"Blood Adv"},{"key":"R8-20260707","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1182\/blood-2015-08-661702","article-title":"Early T-cell precursor acute lymphoblastic leukemia\/lymphoma (ETP-ALL\/LBL) in adolescents and adults: A high-risk subtype","volume":"127","author":"Jain","year":"2016","journal-title":"Blood"},{"key":"R9-20260707","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.3324\/haematol.2019.225078","article-title":"Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia","volume":"105","author":"Genesc\u00e0","year":"2020","journal-title":"Haematologica"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_862_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:16Z","timestamp":1787166856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_862_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_862_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"assertion":[{"value":"2025-08-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}