{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:27:49Z","timestamp":1786739269469,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prostate adenocarcinoma (PC) is commonly known to have bone metastasis but its orbital metastasis is rare accounting for only 8.5% of cases. Most of the reported cases of orbital metastasis are in previously diagnosed PC cases. However, orbital metastasis as a sole manifestation of presentation is extremely rare, and to our knowledge, only three cases have been published similar to our present case. A 72-year-old male presented with diplopia and pain in the right eye for six months. On examination, right eye proptosis was noted. A computed tomography (CT) scan showed an enhancing, destructive soft tissue lesion involving the right orbit. The histopathological evaluation revealed a metastatic adenocarcinoma possibly of prostatic origin. Immunohistochemistry (IHC) confirmed the above diagnosis. We report this unique case of metastatic PC presenting with only ocular manifestation, emphasizing the crucial role played by diagnostic modalities like histopathology and IHC in unraveling such occult dilemmatic scenarios.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_879_23","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:27:26Z","timestamp":1724938046000},"page":"424-427","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The unraveling of a rare case of prostate adenocarcinoma presenting as orbital mass"],"prefix":"10.4103","volume":"68","author":[{"given":"Girish A.","family":"Kadkol","sequence":"first","affiliation":[{"name":"Oncopathology Department, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydeep N.","family":"Pol","sequence":"additional","affiliation":[{"name":"Oncopathology Department, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini V.","family":"Ratnakar","sequence":"additional","affiliation":[{"name":"Department of Pathology, KAHER\u2019s J N Medical College, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal U.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Akashdeep Netralaya, Miraj, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"R1-20250721","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/cancers14010094","article-title":"Orbital metastases: A systematic review of clinical characteristics, management strategies, and treatment outcomes","volume":"14","author":"Palmisciano","year":"2021","journal-title":"Cancers (Basel)"},{"key":"R2-20250721","doi-asserted-by":"crossref","first-page":"NP29","DOI":"10.1177\/1120672119832182","article-title":"Orbital metastasis as presenting symptom from a prostatic adenocarcinoma","volume":"30","author":"Pastore","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"R3-20250721","first-page":"109","article-title":"Orbital metastasis as a first indication of prostate cancer: A case report","volume":"77","author":"Autorino","year":"2005","journal-title":"Arch Ital Urol Androl"},{"key":"R4-20250721","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.eye.6703065","article-title":"Metastatic prostatic adenocarcinoma to the orbit diagnosed by prostate-specific antigen staining","volume":"22","author":"Peng","year":"2008","journal-title":"Eye (Lond)"},{"key":"R5-20250721","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/0145561320973783","article-title":"A rare case of prostate carcinoma metastasis in the orbital apex","volume":"101","author":"Wada","year":"2022","journal-title":"Ear Nose Throat J"},{"key":"R6-20250721","first-page":"103530","article-title":"Orbital metastases from prostate adenocarcinoma: Case report and review of the literature","volume":"76","author":"Nabih","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"R7-20250721","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1259\/bjr.72.862.10673942","article-title":"Features of unusual metastases from prostate cancer","volume":"72","author":"Long","year":"1999","journal-title":"Br J Radiol"},{"key":"R8-20250721","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/djo.djo_58_22","article-title":"Incidence, clinical, and imaging presentation of orbital metastasis over 20 years in a Tertiary Eye Care Center in Egypt","volume":"24","author":"Elbedewy","year":"2023","journal-title":"Delta J Ophthalmol"},{"key":"R9-20250721","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.ophtha.2003.01.002","article-title":"Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1","volume":"111","author":"Shields","year":"2004","journal-title":"Ophthalmology"},{"key":"R10-20250721","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00002341-200109000-00009","article-title":"Cancer metastatic to the orbit: The 2000 Robert M. Curts Lecture","volume":"17","author":"Shields","year":"2001","journal-title":"Ophthalmic Plast Reconstr Surg"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_879_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:27:26Z","timestamp":1786735646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_879_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_879_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2023-11-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}