{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:35Z","timestamp":1787071655004,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Histoplasmosis usually presents as a pulmonary disease. However, histoplasmosis tracheitis is an extremely rare presentation that is often misdiagnosed. We present a case of a 41-year-old female, a known case of systemic sclerosis and chronic kidney disease, on steroids and receiving hemodialysis, who presented with persistent fever, dry cough, and vomiting following recovery from COVID-19 infection. Radiography revealed the presence of cavitating lung lesions, and an initial clinical differential diagnosis of granulomatosis with polyangiitis or tuberculosis was made. Bronchoscopic evaluation, however, revealed the presence of a nodule over the tracheal cartilage, which, on histopathology, revealed sheets of histoplasma-laden histiocytes, allowing a diagnosis of histoplasmosis tracheitis. Histoplasmosis tracheitis is a rare and frequently misdiagnosed condition that can delay treatment and worsen outcomes, underscoring the need for awareness and high clinical suspicion for timely, appropriate intervention.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_881_24","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:00:09Z","timestamp":1749448809000},"page":"846-849","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary histoplasmosis with histoplasmosis tracheitis in a patient with systemic sclerosis: A case report and review of literature"],"prefix":"10.4103","volume":"68","author":[{"given":"Tanvi","family":"Jha","sequence":"first","affiliation":[{"name":"Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desh","family":"Deepak","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"R1-20251208","first-page":"157","article-title":"Histoplasma capsulatum: Mechanisms for pathogenesis","volume":"422","author":"Mittal","year":"2019","journal-title":"Curr Top Microbiol Immunol"},{"key":"R2-20251208","doi-asserted-by":"crossref","first-page":"591974","DOI":"10.3389\/fcimb.2020.591974","article-title":"Cytological and histopathological spectrum of histoplasmosis: 15 years of experience in French Guiana","volume":"10","author":"Drak","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"R3-20251208","first-page":"186","article-title":"Histoplasmosis laryngeal: Report first case in Colombia","volume":"45","author":"Patricia","year":"2014","journal-title":"Colomb M\u00e9d (Cali)"},{"key":"R4-20251208","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/crj.12185","article-title":"Nondisseminated histoplasmosis of the trachea","volume":"10","author":"Bhojwani","year":"2016","journal-title":"Clin Respir J"},{"key":"R5-20251208","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1808-8694(15)31187-3","article-title":"Histoplasmosis of the larynx","volume":"73","author":"Sobrinho","year":"2007","journal-title":"Braz J Otorhinolaryngol"},{"key":"R6-20251208","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1378\/chest.09-0236","article-title":"Tracheal and endobronchial involvement in disseminated histoplasmosis: A case report","volume":"136","author":"Youness","year":"2009","journal-title":"Chest"},{"key":"R7-20251208","doi-asserted-by":"crossref","first-page":"13358","DOI":"10.1111\/tid.13358","article-title":"Unusual cause of hoarse voice: Laryngotracheal histoplasmosis in renal transplant patient","volume":"22","author":"Tiwari","year":"2020","journal-title":"Transpl Infect Dis"},{"key":"R8-20251208","first-page":"A7160","article-title":"An unusual cause of tracheitis","volume":"195","author":"Weiler-Lisowski","year":"2017","journal-title":"ATS Int Conf Abst"},{"key":"R9-20251208","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4103\/lungindia.lungindia_282_17","article-title":"A44-year-old man with hemoptysis","volume":"35","author":"Pangeni","year":"2018","journal-title":"Lung India"},{"key":"R10-20251208","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00027-06","article-title":"Histoplasmosis: A clinical and laboratory update","volume":"20","author":"Kauffman","year":"2007","journal-title":"Clin Microbiol Rev"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_881_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:50:28Z","timestamp":1787068228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_881_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_881_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2024-10-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}