{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:49Z","timestamp":1787761309356,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Progressive external ophthalmoplegia is a slowly progressive hereditary mitochondrial myopathy. Most mitochondrial disorders overlap clinically, enzymatically, and genetically. The most common enzyme defect is the combined deficit of complexes I and IV. Progressive external ophthalmoplegia particularly affects the extraocular muscles and is characterised by ophthalmoplegia, and bilateral ptosis. The ptosis and ophthalmoplegia is unresponsive to anticholinergics, with no effective treatment, but corrective surgery for ptosis as a palliative one. In this article, we report a rare case of a 16-year-old female with characterstic histological features consistent with progressive external ophthalmoplegia.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_893_21","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:37:53Z","timestamp":1673570273000},"page":"883-885","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Progressive external ophthalmoplegia \u2013 A case report"],"prefix":"10.4103","volume":"66","author":[{"given":"Ashmeet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusum","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Harsh","sequence":"additional","affiliation":[{"name":"Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Thakar","sequence":"additional","affiliation":[{"name":"Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3390\/jcm10061249","article-title":"Mitochondrial syndromes revisited","volume":"10","author":"Orsucci","year":"2021","journal-title":"J Clin Med"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"760","DOI":"10.4103\/0028-3886.293454","article-title":"Clinicogenetical variants of progressive external ophthalmoplegia-An especial review of non-ophthalmic manifestations","volume":"68","author":"Maghbooli","year":"2020","journal-title":"Neurol India"},{"key":"R3-20240829","first-page":"436","article-title":"Chronic progressive external ophthalmoplegia","volume":"58","author":"Axel","year":"1996","journal-title":"J Natl Med Assoc"},{"key":"R4-20240829","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-010181","article-title":"Progressive external ophthalmoplegia (PEO) due to a mutation in the C10orf2 (PEO1) gene mimicking a myasthenic crisis","author":"Gonzalez-Moron","year":"2013","journal-title":"BMJ Case Rep 2013"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJM198905183202001","article-title":"Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome","volume":"320","author":"Moraes","year":"1989","journal-title":"N Engl J Med"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ymgme.2015.06.004","article-title":"MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options","volume":"116","author":"El-Hattab","year":"2015","journal-title":"Mol Genet Metab"},{"key":"R7-20240829","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/287432","article-title":"Mitochondrial sensorineural hearing loss: A retrospective study and a description of cochlear implantation in a MELAS patient","author":"Scarpelli","year":"2012","journal-title":"Genet Res Int 2012"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00415-015-7710-y","article-title":"Redefining phenotypes associated with mitochondrial DNA single deletion","volume":"262","author":"Mancuso","year":"2015","journal-title":"J Neurol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_893_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:43Z","timestamp":1787758303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_893_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_893_21","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]},"assertion":[{"value":"2021-09-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}