{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:11Z","timestamp":1787070911644,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic enteropathy associated with the\n                    <jats:italic toggle=\"yes\">SLCO2A1<\/jats:italic>\n                    gene (CEAS) is a rare, autosomal recessive disorder characterized by multiple chronic ulcerative and structuring lesions in the small intestine, primarily affecting the ileum. It often presents with symptoms of chronic blood loss and protein loss, including iron deficiency anemia and abdominal pain, similar to other nonspecific small bowel enteropathies. This case report describes a 15-year-old boy with a 10-year history of recurrent abdominal pain, melena, anemia, and hypoalbuminemia. Initial clinical, endoscopic, and radiological findings suggested inflammatory bowel disease, which led to trials of various therapies, including corticosteroids, antivirals, and biologicals, with incomplete remission. Molecular analysis identified a homozygous\n                    <jats:italic toggle=\"yes\">SLCO2A1<\/jats:italic>\n                    gene mutation, confirming CEAS. Histopathology revealed extensive mucosal ulceration and submucosal fibrosis in the ileum, with repeat biopsies showing chronic inflammation and villous atrophy. The case underscores the need for comprehensive clinical, histopathological, and molecular evaluation in pediatric patients presenting with chronic nonspecific small bowel ulcers to ensure accurate diagnosis and management of CEAS. This report also adds to the limited global literature on CEAS, being the first documented case in India with a unique exon 11 mutation in\n                    <jats:italic toggle=\"yes\">SLCO2A1<\/jats:italic>\n                    , contributing to the understanding of disease heterogeneity in non-consanguineous populations.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_899_24","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:00:10Z","timestamp":1747969210000},"page":"583-588","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Monogenic SLCO2A1 gene mutation presenting as early onset inflammatory bowel disease-A report of rare case with review of literature"],"prefix":"10.4103","volume":"68","author":[{"given":"Mukund Namdev","family":"Sable","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shameema Farween","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susama","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saswati","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash Chandra","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"R1-20251031","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ecco-jcc\/jjx068","article-title":"Chronic enteropathy associated with SLCO2A1 gene [CEAS]-characterisation of an enteric disorder to be considered in the differential diagnosis of Crohn's disease","volume":"11","author":"Hosoe","year":"2017","journal-title":"J Crohns Colitis"},{"key":"R2-20251031","doi-asserted-by":"crossref","first-page":"107803","DOI":"10.1016\/j.pharmthera.2021.107803","article-title":"Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action","volume":"223","author":"Nakanishi","year":"2021","journal-title":"Pharmacol Ther"},{"key":"R3-20251031","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1038\/jid.2012.146","article-title":"Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing","volume":"132","author":"Busch","year":"2012","journal-title":"J Invest Dermatol"},{"key":"R4-20251031","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.3748\/wjg.v30.i19.2505","article-title":"Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene:Hypotheses and conundrums","volume":"30","author":"Xie","year":"2024","journal-title":"World J Gastroenterol"},{"key":"R5-20251031","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/ecco-jcc\/jjac181","article-title":"Crohn-like disease affecting small bowel due to monogenic SLCO2A1 mutations:First cases of chronic enteropathy associated with SLCO2A1 gene [CEAS] in France","volume":"17","author":"Hamon","year":"2023","journal-title":"J Crohns Colitis"},{"key":"R6-20251031","first-page":"350","article-title":"Primary nonspecific small bowel ulceration as a source of chronic bleeding. Report of a case and review of the approach to localization of the site of small bowel hemorrhage","volume":"62","author":"Graham","year":"1974","journal-title":"Am J Gastroenterol"},{"key":"R7-20251031","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00535-017-1426-y","article-title":"Clinical features of chronic enteropathy associated with SLCO2A1 gene:A new entity clinically distinct from Crohn's disease","volume":"53","author":"Umeno","year":"2018","journal-title":"J Gastroenterol"},{"key":"R8-20251031","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s12887-020-02333-0","article-title":"Obscure gastrointestinal bleeding caused by congenital enteropathy in a Chinese young child-a case report","volume":"20","author":"Fang","year":"2020","journal-title":"BMC Pediatr"},{"key":"R9-20251031","doi-asserted-by":"crossref","first-page":"942","DOI":"10.5009\/gnl210415","article-title":"IBD research group of the Korean association for the study of intestinal diseases. Clinical and genetic characteristics of Korean patients diagnosed with chronic enteropathy associated with SLCO2A1 gene:A KASID multicenter study","volume":"16","author":"Hong","year":"2022","journal-title":"Gut Liver"},{"key":"R10-20251031","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1007\/s10620-020-06629-0","article-title":"Four variants of SLCO2A1 identified in three Chinese patients with chronic enteropathy associated with the SLCO2A1 gene","volume":"66","author":"Huang","year":"2021","journal-title":"Dig Dis Sci"},{"key":"R11-20251031","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12887-024-04877-x","article-title":"Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease","volume":"24","author":"Lim","year":"2024","journal-title":"BMC Pediatr"},{"key":"R12-20251031","doi-asserted-by":"crossref","first-page":"46","DOI":"10.18528\/ijgii240003","article-title":"Arare cause of obscure gastrointestinal bleeding:Chronic enteropathy associated with SLCO2A1 mutation in a case from India","volume":"13","author":"Chopra","year":"2024","journal-title":"Int J Gastrointest Interv"},{"key":"R13-20251031","article-title":"Chronic enteropathy associated with SLCO2A1 gene (CEAS) in Indian adolescents:Apropos of two cases","author":"Kumar","year":"2024","journal-title":"Indian J Gastroenterol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_899_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:46Z","timestamp":1787067526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_899_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_899_24","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"assertion":[{"value":"2024-10-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}