{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:50:35Z","timestamp":1788969035280,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Rhabdomyolysis is a potentially life-threatening clinical syndrome characterized by the breakdown of skeletal muscle cells and release of creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin into the plasma and interstitial space. Rhabdomyolysis can occur due to a variety of causes and acute kidney injury (AKI) is one of its most dreaded complications occurring in 33%\u201350% patients. The main pathophysiology of renal injury is due to vasoconstriction, intraluminal casts, tubular obstruction, and direct myoglobin toxicity. As the symptoms are nonspecific, a high level of suspicion is required in the mind of the treating physician. Early diagnosis and prompt management with fluid resuscitation, initiation of renal replacement therapy (RRT), and elimination of causative agents can help prevent complications. We hereby report four interesting cases of this clinical syndrome with emphasis on the causative agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_89_20","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:11:46Z","timestamp":1717042306000},"page":"382-384","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Rhabdomyolysis with myoglobin-induced acute kidney injury"],"prefix":"10.4103","volume":"64","author":[{"given":"Hanock Unni","family":"Samuel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Balasubramaniyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thirumavalavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Senthil Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Murugesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-30-20240829","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1001\/archinte.1979.03630430010005","article-title":"Serum myoglobin","volume":"139","author":"Kagen","year":"1979","journal-title":"Arch Inter Med"},{"key":"R2-30-20240829","first-page":"619","article-title":"Studies of mechanisms and protective manoeuvres in myoglobinuric acute renal injury","volume":"60","author":"Zager","year":"1989","journal-title":"Lab Invest"},{"key":"R3-30-20240829","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/bjaceaccp\/mkl027","article-title":"Rhabdomyolysis","volume":"6","author":"Hunter","year":"2006","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"key":"R4-30-20240829","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000020651","article-title":"Pathogenesis of renal failure in rhabdomyolysis: The role of myoglobin","volume":"8","author":"Holt","year":"2000","journal-title":"Nephron Exp Nephrol"},{"key":"R5-30-20240829","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ki.1996.48","article-title":"Rhabdomyolysis and myohemoglobinuric acute renal failure","volume":"49","author":"Zager","year":"1996","journal-title":"Kidney Inter"},{"key":"R6-30-20240829","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/j.ajkd.2016.12.002","article-title":"Atlas of renal pathology: Myoglobin cast nephropathy","volume":"69","author":"Najafian","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"R7-30-20240829","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1681\/ASN.V1181553","article-title":"Rhabdomyolysis","volume":"11","author":"Van holder","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"R8-30-20240829","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1381\/096089203764467252","article-title":"Pressure-induced rhabdomyolysis after bariatric surgery","volume":"13","author":"Torres","year":"2003","journal-title":"Obes Surg"},{"key":"R9-30-20240829","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.humpath.2016.02.026","article-title":"Myoglobin casts in renal biopsies: Immunohistochemistry and morphologic spectrum","volume":"54","author":"Liapis","year":"2016","journal-title":"Hum Pathol"},{"key":"R10-30-20240829","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.kint.2019.08.026","article-title":"Haemolysis-associated haemoglobin cast nephropathy results from a range of clinicopathologic disorders","volume":"96","author":"Dvanajscak","year":"2019","journal-title":"Kidney Inter"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_89_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:31:49Z","timestamp":1787067109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_89_20"}},"subtitle":["A case series of four cases"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_89_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}