{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:32:55Z","timestamp":1787772775039,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Background:<\/jats:title>\n \n Cystic Hypersecretory Carcinoma (CHC) is a rare subset of breast carcinoma. It is part of a spectrum of cystic hypersecretory lesions which includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC\n in situ<\/jats:italic>\n and CHC with invasion. Approximately 65 cases of cystic hypersecretory lesions have been reported; most of them were CHC\n in situ<\/jats:italic>\n and only 19 cases of CHC with invasion have been reported so far.\n <\/jats:p>\n <\/jats:sec>\n \n Case Presentation:<\/jats:title>\n \n We are reporting 2 cases of 47 and 62 year old women with a palpable breast mass for 6 and 1 month duration respectively. Trucut biopsy was carried out for both which showed high grade ductal carcinoma\n in situ<\/jats:italic>\n with microinvasion in the first patient and the latter showed a tiny focus of invasive carcinoma. Simple mastectomy and modified radical mastectomy (MRM) were done for the respective cases; both showed dilated cystic spaces filled with eosinophilic secretions (thyroid colloid-like), lining neoplastic cells that showed variable degrees of proliferation, atypia and\n in situ<\/jats:italic>\n carcinoma. There were foci of invasion in both cases and hence a morphological diagnosis of CHC with invasion was made.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Owing to a smaller number of reported cases, little is known about the biological behavior, prognosis and molecular profile of cystic hypersecretory carcinoma.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_911_20","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T14:43:14Z","timestamp":1724942594000},"page":"149-151","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Cystic hypersecretory carcinoma with invasion"],"prefix":"10.4103","volume":"65","author":[{"given":"Hibu","family":"Yami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Thambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PV","family":"Priya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankar","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-27-20240829","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s11604-011-0601-y","article-title":"Cystic hypersecretory ductal carcinoma of the breast: A rare cause of cystic breast mass","volume":"29","author":"Song","year":"2011","journal-title":"Jap J Radiol"},{"key":"R3-27-20240829","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00000478-198401000-00003","article-title":"Cystic hypersecretory duct carcinoma of the breast","volume":"8","author":"Rosen","year":"1984","journal-title":"Am J Surg Pathol"},{"key":"R4-27-20240829","first-page":"16","article-title":"Invasive cystic hypersecretory carcinoma of breast: A rare and under diagnosed variant of ductal carcinoma","volume":"11","author":"Sahoo","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"R5-27-20240829","first-page":"115","article-title":"Invasive cystic hypersecretory ductal carcinoma of the breast","volume":"4","author":"Kamer","year":"2008","journal-title":"J Breast Health"},{"key":"R6-27-20240829","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/PAS.0b013e31829fc47b","article-title":"Cystic hypersecretory (in situ) carcinoma of the breast: A clinicopathologic and immunohistochemical characterization of 10 cases with clinical follow-up","volume":"38","author":"D'Alfonso","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"R7-27-20240829","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12885-018-5260-2","article-title":"Invasive cystic hypersecretory carcinoma of the breast: A rare variant of breast cancer: A case report and review of the literature","volume":"19","author":"Sun","year":"2019","journal-title":"BMC Cancer"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_911_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:12:10Z","timestamp":1787771530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_911_20"}},"subtitle":["Case series on a rare variant of carcinoma breast"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_911_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}