{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:44Z","timestamp":1787841104054,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oncocytic subtypes of adrenocortical carcinomas are rare tumor entities, with relatively better prognosis than the conventional subtype. Owing to its rarity, oncocytic adrenocortical carcinomas (OACCs) have not been studied extensively. The study aims to analyze the clinicopathological and therapy-relevant immunohistochemical profile of OACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 14 cases of OACC were retrieved and reviewed. Relevant clinical, demographic, and histopathological information with respect to various scoring systems was collected. Immunohistochemical evaluation for SF1, beta-catenin, insulin-like growth factor-1 receptor, and ki-67 was performed, and results were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion:<\/jats:title>\n                    <jats:p>The age range distribution is diverse and estimation of malignant potential using Lin\u2013Weiss Bisceglia scoring criteria of OACC is of paramount importance. Beta-catenin can be applied as a useful marker for prognostication of OACCs. Insulin growth factor-2 overexpression of conventional adrenocortical carcinomas must not be extrapolated to the oncocytic variant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_921_25","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:00:30Z","timestamp":1774936830000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Oncocytic adrenocortical carcinomas: A clinicopathological and immunohistochemical review of 14 cases of a rare entity"],"prefix":"10.4103","volume":"69","author":[{"given":"Niraj","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Surgical Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Surgical Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Krishnani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"R2-20260403","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.humpath.2010.08.010","article-title":"Oncocytic adrenocortical neoplasms\u2014A clinicopathologic study of 13 new cases emphasizing the importance of their recognition","volume":"42","author":"Wong","year":"2011","journal-title":"Hum Pathol"},{"key":"R3-20260403","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/biomedicines9020175","article-title":"Adrenocortical carcinoma:Updates of clinical and pathological features after renewed World Health Organisation classification and pathology staging","volume":"9","author":"Lam","year":"2021","journal-title":"Biomedicines"},{"key":"R4-20260403","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/106689690401200304","article-title":"Adrenocortical oncocytic tumors:Report of 10 cases and review of 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Clin Endocrinol Metab"},{"key":"R8-20260403","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1210\/jc.2009-2040","article-title":"Steroidogenic factor 1 Overexpression and gene amplification are more frequent in adrenocortical tumors from children than from adults","volume":"95","author":"Almeida","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-20260403","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1124\/mol.107.040089","article-title":"Identification of the first synthetic steroidogenic factor 1 inverse agonists:Pharmacological modulation of steroidogenic enzymes","volume":"73","author":"Tredici","year":"2008","journal-title":"Mol Pharmacol"},{"key":"R10-20260403","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12957-015-0527-4","article-title":"Diagnostic and prognostic features in adrenocortical carcinoma:A single institution case series and review of the literature","volume":"13","author":"Wanis","year":"2015","journal-title":"World J Surg Oncol"},{"key":"R11-20260403","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1158\/1078-0432.CCR-10-2006","article-title":"?-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma","volume":"17","author":"Gaujoux","year":"2011","journal-title":"Clin Cancer Res"},{"key":"R12-20260403","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.3390\/cancers13174383","article-title":"How to differentiate benign from malignant adrenocortical tumors?","volume":"13","author":"Vi\u00ebtor","year":"2021","journal-title":"Cancers (Basel)"},{"key":"R13-20260403","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/biomedicines9020174","article-title":"The role of biomarkers in adrenocortical carcinoma:A review of current evidence and future perspectives","volume":"9","author":"Mizdrak","year":"2021","journal-title":"Biomedicines"},{"key":"R14-20260403","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1210\/endrev\/bnac012","article-title":"Update on biology and genomics of adrenocortical carcinomas:Rationale for emerging therapies","volume":"43","author":"Lerario","year":"2022","journal-title":"Endocr Rev"},{"key":"R15-20260403","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00280-009-1083-9","article-title":"Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma","volume":"65","author":"Haluska","year":"2010","journal-title":"Cancer Chemother Pharmacol"}],"container-title":["Indian Journal of Pathology and 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