{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:08Z","timestamp":1787772488235,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Eosinophilic solid and cystic renal cell carcinoma (ESCRCC) is an under-recognized, emerging new entity of sporadic renal neoplasms, with an approximate incidence of 0.2% of renal tumors. A total of 60 cases have been reported in the literature till date. ESCRCC are usually seen in adult females, with a low stage and indolent behavior, and rare incidence of recurrence or metastasis. They are solid and cystic tumors with variably sized cysts resembling eosinophilic RCC, showing a characteristic positive immune-expression for PAX-8, CK20 (in ~80% cases) and\/or Melan\u2013A (in ~6.7%), with negative CK7 and CA-IX expression. They consistently harbor TSC1 or TSC2 mutations in all tumors, which is a proposed molecular marker for this entity. We here present the first reported case of this rare tumor from India. The tumor was positive for PAX-8, and showed diffuse strong positivity for Melan-A, while was negative for CK7 and CK20. It was an early-stage tumor (T1), managed with partial nephrectomy, with no evidence of any recurrence\/metastasis after 1 year of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_938_20","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:19:44Z","timestamp":1717042784000},"page":"799-801","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilic solid and cystic renal cell carcinoma"],"prefix":"10.4103","volume":"64","author":[{"given":"Meenakshi","family":"Kamboj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurudutt","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Pasricha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Rawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Durga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-33-20240829","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/1066896909333510","article-title":"Distinctive morphology of renal cell carcinomas in tuberous sclerosis","volume":"18","author":"Schreiner","year":"2010","journal-title":"Int J Surg Pathol"},{"key":"R2-33-20240829","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/PAS.0000000000000508","article-title":"Eosinophilic, solid, and cystic renal cell carcinoma clinicopathologic study of 16 unique, sporadic neoplasms occurring in women","volume":"40","author":"Trpkov","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"R3-33-20240829","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/his.13727","article-title":"New and emerging renal entities: A perspective post-WHO 2016 classification","volume":"74","author":"Trpkov","year":"2019","journal-title":"Histopathology"},{"key":"R4-33-20240829","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/PAS.0000000000000838","article-title":"Eosinophilic solid and cystic renal cell carcinoma (ESCRCC): Further morphologic and molecular characterization of ESCRCC as a distinct entity","volume":"41","author":"Trpkov","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"R5-33-20240829","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/his.13395","article-title":"Re-evaluation of 33 'unclassified' eosinophilic renal cell carcinomas in young patients","volume":"72","author":"Li","year":"2018","journal-title":"Histopathology"},{"key":"R6-33-20240829","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.humpath.2018.05.023","article-title":"Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid angiomyolipoma: Series of 4 primary tumors and 2 metastases","volume":"80","author":"Tretiakova","year":"2018","journal-title":"Human Pathol"},{"key":"R8-33-20240829","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/his.13457","article-title":"Eosinophilic solid and cystic renal cell carcinomas have metastatic potential","volume":"72","author":"McKenney","year":"2017","journal-title":"Histopathology"},{"key":"R9-33-20240829","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/PAS.0000000000001111","article-title":"Eosinophilic solid and cystic (ESC) renal cell carcinomas harbor TSC mutations: Molecular analysis supports an expanding clinicopathologic spectrum","volume":"42","author":"Palsgrove","year":"2018","journal-title":"Am J Surg Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_938_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:49:38Z","timestamp":1787770178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_938_20"}},"subtitle":["A rare under-recognized indolent entity"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_938_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}