{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:29:58Z","timestamp":1787070598031,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Chronic Myeloid Leukemia, BCR-ABL1 positive (CML) is distinct from other myeloproliferative neoplasms (MPNs) as it is positive for the Philadelphia chromosome (Ph) with presence of\n                      <jats:italic toggle=\"yes\">BCR-ABL1<\/jats:italic>\n                      translocation that makes it responsive to targeted therapy with tyrosine kinase inhibitors (TKI). Distinctly there is another group of Ph-negative myeloproliferative neoplasms as polycythemia vera (PV), primary myelofibrosis (PMF), essential thrombocythemia (ET) and others that harbor an activating mutation in the Janus Kinase 2 gene (\n                      <jats:italic toggle=\"yes\">JAK2<\/jats:italic>\n                      ), i.e.,\n                      <jats:italic toggle=\"yes\">JAK2<\/jats:italic>\n                      V617F mutation.\n                      <jats:italic toggle=\"yes\">BCR-ABL1<\/jats:italic>\n                      translocation and the\n                      <jats:italic toggle=\"yes\">JAK2<\/jats:italic>\n                      V617F mutation are generally considered disease defining and mutually exclusive due to diagnostic and therapeutic implications. We hereby present a rare case of MPN with coexistent expression of\n                      <jats:italic toggle=\"yes\">BCR-ABL1<\/jats:italic>\n                      translocation and\n                      <jats:italic toggle=\"yes\">JAK2<\/jats:italic>\n                      V617F mutation thus posing a challenge in diagnosis, treatment, and follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpm.ijpm_977_20","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:19:44Z","timestamp":1717042784000},"page":"820-823","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A case of double positive myeloproliferative neoplasm"],"prefix":"10.4103","volume":"64","author":[{"given":"Ayeesha B","family":"Shaikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Aribandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh K.","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-39-20240829","first-page":"116","article-title":"Detection of Jak2 V617f mutation, secondary to the presence of Bcr-Abl1 translocation in a patient with chronic myeloid leukemia: Report of a case and review of the literature","volume":"2","author":"Carranza","year":"2014","journal-title":"Int J Genomic Med"},{"key":"R3-39-20240829","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/sj.leu.2405088","article-title":"JAK2V617F-positive polycythemia vera and Philadelphia chromosome-positive chronic myeloid leukemia: One patient with two distinct myeloproliferative disorders","volume":"22","author":"Cambier","year":"2008","journal-title":"Leukemia"},{"key":"R4-39-20240829","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12185-009-0471-6","article-title":"A man with concomitant polycythaemia vera and chronic myeloid leukemia: The dynamics of the two disorders","volume":"91","author":"Bee","year":"2010","journal-title":"Int J Hematol"},{"key":"R5-39-20240829","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.1038\/bcj.2015.77","article-title":"Concomitant JAK2 V617F-positive polycythemia vera and BCR-ABL-positive chronic myelogenous leukemia treated with ruxolitinib and dasatinib","volume":"5","author":"Zhou","year":"2015","journal-title":"Blood Cancer J"},{"key":"R6-39-20240829","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/bjh.13932","article-title":"BCR-ABL1-positive and JAK2 V617F-positive clones in 23 patients with both aberrations reveal biologic and clinical importance","volume":"176","author":"Martin-Cabrera","year":"2017","journal-title":"Br J Haematol"},{"key":"R7-39-20240829","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1182\/blood-2011-07-365007","article-title":"Concomitant occurrence of BCR-ABL and JAK2V617F mutation","volume":"118","author":"Pieri","year":"2011","journal-title":"Blood"},{"key":"R8-39-20240829","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1111\/ijlh.12010","article-title":"Concomitant detection of BCR-ABL translocation and JAK2 V617F mutation in five patients with myeloproliferative neoplasm at diagnosis","volume":"35","author":"Cappetta","year":"2013","journal-title":"Int J Lab Hematol"},{"key":"R9-39-20240829","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jmoldx.2013.07.002","article-title":"Laboratory practice guidelines for detecting and reporting JAK2 and MPL mutations in myeloproliferative neoplasms: A report of the association for molecular pathology","volume":"15","author":"Gong","year":"2013","journal-title":"J Mol Diagn"},{"key":"R10-39-20240829","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.leu.2404993","article-title":"Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation","volume":"22","author":"Hussein","year":"2008","journal-title":"Leukemia"},{"key":"R11-39-20240829","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1182\/blood-2012-11-467787","article-title":"BCR-ABL1 is a secondary event after JAK2V617F in patients with polycythemia vera who develop chronic myeloid leukemia","volume":"121","author":"Wang","year":"2013","journal-title":"Blood"},{"key":"R12-39-20240829","first-page":"1","article-title":"Concurrent JAK2-positive myeloproliferative disorder and chronic myelogenous leukemia: A novel entity? A case report with review of the literature","volume":"7","author":"Bader","year":"2019","journal-title":"J Investig Med High Impact Case Rep"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_977_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:31:43Z","timestamp":1787067103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJPM.IJPM_977_20"}},"subtitle":["A diagnostic and therapeutic challenge"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_977_20","relation":{},"ISSN":["0377-4929"],"issn-type":[{"value":"0377-4929","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}