{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:30Z","timestamp":1786728630362,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Karyomegalic interstitial nephritis (KIN) is an uncommon autosomal recessive disease, which is characterized by enlarged and hyperchromatic nuclei of the renal tubular epithelial cells. It is associated with mutations in Fanconi anemia-associated nuclease 1 gene, which is responsible for DNA repair, and these pathogenic mutations are responsible for progressive renal failure in young adults. We present a case of a 29-year-old female with end-stage renal disease who had a family history of early-onset renal failure in two of the siblings. Her elder sister with chronic kidney disease stage III was advised to be biopsied to look for any familial causes. Stained sections of renal biopsy revealed normal glomeruli. Tubular epithelial cells showed nuclear changes focally like hyperchromasia, karyomegaly, and anisonucleosis. On direct immunofluorescence, all glomeruli were negative for deposits with all antisera. Based on these findings, a final opinion of KIN was given.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_984_23","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T06:00:30Z","timestamp":1717740030000},"page":"428-430","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Karyomegalic interstitial nephritis, a fascinating histopathologic entity for pathologists: Be watchful of the FAN1 gene mutations"],"prefix":"10.4103","volume":"68","author":[{"given":"Gurpreet K.","family":"Walia","sequence":"first","affiliation":[{"name":"Department of Pathology, Command Hospital Airforce, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesha","family":"Vankalakunti","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Manipal Hospitals, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanjit S.","family":"Akal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Command Hospital Airforce, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijoy K.","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Base Hospital, Delhi Cantt, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"R1-20250721","doi-asserted-by":"crossref","first-page":"e3349","DOI":"10.1097\/MD.0000000000003349","article-title":"Karyomegalic interstitial nephritis: A case report and review of the literature","volume":"95","author":"Isnard","year":"2016","journal-title":"Medicine"},{"key":"R2-20250721","doi-asserted-by":"crossref","first-page":"e2021343","DOI":"10.4322\/acr.2021.343","article-title":"Association of karyomegalic interstitial 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glomerulosclerosis","volume":"3","author":"Mehta","year":"2020","journal-title":"JMCRR"},{"key":"R6-20250721","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12882-020-01733-9","article-title":"Karyomegalic interstitial nephritis with a novel FAN1 gene mutation and concurrent ALECT2 amyloidosis","volume":"21","author":"Law","year":"2020","journal-title":"BMC Nephrol"},{"key":"R7-20250721","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s13730-015-0183-0","article-title":"Karyomegalic interstitial nephritis","volume":"5","author":"Bennani Guebessi","year":"2016","journal-title":"CEN Case Rep"},{"key":"R8-20250721","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1053\/j.ajkd.2016.10.007","article-title":"AJKD Atlas of renal pathology: Polyomavirus nephropathy","volume":"68","author":"Lusco","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"R9-20250721","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12920-021-01009-7","article-title":"New familial cases of karyomegalic interstitial nephritis with mutations in the FAN1 gene","volume":"14","author":"Rejeb","year":"2021","journal-title":"BMC Med Genomics"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_984_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:29:31Z","timestamp":1786724971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_984_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_984_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2023-12-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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