{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:17Z","timestamp":1787762057246,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pseudomyogenic hemangioendothelioma (PHE) is an uncommon mesenchymal neoplasm of intermediate malignant potential showing endothelial differentiation. Around 20 cases of primary osseous PHE have been reported to date. A 16-year-old boy presented with complaints of pain in his right leg. Imaging revealed multifocal intramedullary and cortical-based lytic lesions involving long and small bones. Microscopic examination revealed plump, spindled cells arranged in fascicles and admixed \u201cepithelioid\u201d and \u201crhabdoid\u201d cells\n                    <jats:italic toggle=\"yes\">sans<\/jats:italic>\n                    vasoformative areas. By immunohistochemistry, the lesional cells were reactive for AE1\/AE3, CD31, Erg, Fli1, and SMA, while immunonegative for CD34, myogenin, and S100. Nuclear expression of the INI1\/SMARCB1 protein was retained. PHE is a rare entity, more so as a primary osseous lesion; therefore, awareness of the presence of this entity in the bone is the key to making a diagnosis. We discuss its clinicopathological features, differential diagnosis, and an attempt a short review of the literature.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_995_22","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T02:44:52Z","timestamp":1690253092000},"page":"661-664","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Multifocal intraosseous pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma: A rare presentation of an uncommon tumor"],"prefix":"10.4103","volume":"67","author":[{"given":"Vishwapriya M.","family":"Godkhindi","sequence":"first","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Monappa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharada","family":"Mailankody","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiab M. V.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisharya","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/PAS.0b013e3181ff0901","article-title":"Pseudomyogenic hemangioendothelioma:a distinctive, often multicentric tumor with indolent behavior","volume":"35","author":"Hornick","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.anndiagpath.2019.06.003","article-title":"Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma of bone:Clinicopathologic features of 5 cases","volume":"41","author":"Kosemehmetoglu","year":"2019","journal-title":"Ann Diagn Pathol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1066896920951841","article-title":"Two cases of intraosseous pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma with unusual features, expanding the clinicopathological spectrum","volume":"29","author":"Rekhi","year":"2021","journal-title":"Int J Surg Pathol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/0377-4929.188144","article-title":"A rare case of multifocal pseudomyogenic hemangioendothelioma, involving soft tissues and bone, misdiagnosed as a rhabdomyosarcoma:Diagnostic and treatment implications","volume":"59","author":"Rekhi","year":"2016","journal-title":"Indian J Pathol Microbiol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/PAS.0000000000000613","article-title":"Primary pseudomyogenic hemangioendothelioma of bone","volume":"40","author":"Inyang","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.1002\/dc.24606","article-title":"Cytomorphological features of an unusual case of a multifocal pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma in a young adult male","volume":"49","author":"Rekhi","year":"2021","journal-title":"Diagn Cytopathol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1186\/s12885-019-6072-8","article-title":"Pseudomyogenic hemangioendothelioma of bone treated with denosumab:A case report","volume":"19","author":"Otani","year":"2019","journal-title":"BMC Cancer"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1097\/MPH.0000000000000778","article-title":"Everolimus for treatment of pseudomyogenic hemangioendothelioma","volume":"39","author":"Ozeki","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1097\/PAS.0000000000001147","article-title":"Expanding the spectrum of genetic alterations in pseudomyogenic hemangioendothelioma with recurrent novel ACTB-FOSB gene fusions","volume":"42","author":"Agaram","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"293","DOI":"10.21873\/cgp.20134","article-title":"Fusion of the genes WWTR1 and FOSB in pseudomyogenic hemangioendothelioma","volume":"16","author":"Panagopoulos","year":"2019","journal-title":"Cancer Genomics Proteomics"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_995_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:16:18Z","timestamp":1787760978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_995_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_995_22","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]},"assertion":[{"value":"2022-12-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}