{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:31:16Z","timestamp":1787070676227,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Central nervous system involvement is a rare complication of Waldenstrom macroglobulinemia (WM) accounting for 1\u20132% cases. This syndrome is called Bing\u2013Neel syndrome (BNS) after the people who first described it in 1936. Although WM has a good prognosis, with the onset of this syndrome, most patients fare poorly with a high mortality rate. A 77\/male, a known case of WM, presented with left upper limb weakness of 2 weeks duration. Magnetic resonance imaging brain showed diffuse pachymeningeal thickening along bilateral frontoparietal convexity. Biopsy showed lymphoplasmacytic lymphoma favoring a diagnosis of BNS. The patient was started on chemotherapy (rituximab + ibrutinib). At 3 months following diagnosis, the patient was admitted with Gram-negative septicemic shock and failed to recover from it. BNS is a rare complication of WM, associated with poor prognosis and an aggressive clinical course. It can occur during the course of treatment of WM, as was seen in this case. Accurate diagnosis with appropriate treatment plays a crucial role in patient management.<\/jats:p>","DOI":"10.4103\/ijpm.ijpm_997_23","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T06:00:42Z","timestamp":1717740042000},"page":"405-407","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bing\u2013Neel syndrome: A rare complication of waldenstrom macroglobulinemia"],"prefix":"10.4103","volume":"68","author":[{"given":"Ranjini","family":"Kudva","sequence":"first","affiliation":[{"name":"Department of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Monappa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Menon","sequence":"additional","affiliation":[{"name":"Department Neurosurgery, Kasturba Medical College and Kasturba Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"R2-20250721","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/bjh.13883","article-title":"Central nervous system involvement by Waldenstr\u00f6m macroglobulinaemia (Bing-Neel syndrome): A multi-institutional retrospective study","volume":"172","author":"Castillo","year":"2016","journal-title":"Br J Haematol"},{"key":"R3-20250721","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.0954-6820.1936.tb12571.x","article-title":"Two cases of hyperglobulinaemia with affection of the central nervous system on a toxi-infectious basis","volume":"88","author":"Bing","year":"1936","journal-title":"Acta Med Scand"},{"key":"R4-20250721","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.0954-6820.1944.tb03955.x","article-title":"Incipient myelomatosis or \u201cessential\u201d hyperglobulinemia with fibrinogenopenia - A new syndrome?","volume":"117","author":"Waldenstr\u00f6m","year":"1944","journal-title":"Acta Med Scand"},{"key":"R5-20250721","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00428-019-02698-3","article-title":"Lymphomas arising in immuneprivileged sites: Insights into biology, diagnosis, and pathogenesis","volume":"476","author":"King","year":"2020","journal-title":"Virchows Arch"},{"key":"R6-20250721","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/sonc.2003.50082","article-title":"Clinicopathological definition of Waldenstrom's macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia","volume":"30","author":"Owen","year":"2003","journal-title":"Semin Oncol"},{"key":"R7-20250721","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3324\/haematol.2016.147728","article-title":"Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome","volume":"102","author":"Minnema","year":"2017","journal-title":"Haematologica"},{"key":"R8-20250721","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1182\/blood-2008-08-174961","article-title":"International prognostic scoring system for Waldenstrom macroglobulinemia","volume":"113","author":"Morel","year":"2009","journal-title":"Blood"},{"key":"R9-20250721","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1177\/1078155220983426","article-title":"Bing-Neel syndrome: A case reports","volume":"27","author":"Demircio\u011flu","year":"2021","journal-title":"J Oncol Pharm Pract"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_997_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:34:42Z","timestamp":1787067282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijpm.ijpm_997_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_997_23","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"assertion":[{"value":"2023-12-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}