{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:25:52Z","timestamp":1783416352992,"version":"3.54.6"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Malignant gastrointestinal neuroectodermal tumor (MGNET) is a rare and highly aggressive malignancy originating in the gastrointestinal tract. It resembles various gastrointestinal mesenchymal tumors in appearance and microscopic morphology. While typical immunohistochemistry aids diagnosis, abnormal immunophenotypes can complicate it. We report a case of MGNET in the transverse colon in a 37-year-old man. Immunohistochemical results showed DOG1 positivity and S100 negativity, mimicking CD117-negative\/DOG1-positive gastrointestinal stromal tumors (GIST). Fluorescence\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization (FISH) revealed\n                    <jats:italic toggle=\"yes\">EWSR1<\/jats:italic>\n                    gene rearrangement, and next-generation sequencing (NGS)-based\n                    <jats:italic toggle=\"yes\">RNA<\/jats:italic>\n                    fusion gene detection identified EWSR1::ATF1 fusion, supporting the diagnosis of MGNET. We will discuss the abnormal immunophenotype and differential diagnosis of MGNET, reviewing relevant literature.\n                  <\/jats:p>","DOI":"10.4103\/ijpm.ijpm_9_25","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:54:49Z","timestamp":1782852889000},"page":"354-357","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Malignant gastrointestinal neuroectodermal tumor of the colon showing DOG1 positivity and S100 negativity: A case report"],"prefix":"10.4103","volume":"69","author":[{"given":"JiaSi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Yichun People\u2019s Hospital, Yichun, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yichun People\u2019s Hospital, Yichun, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiXiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yichun People\u2019s Hospital, Yichun, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, 251Hospital of PLA, Zhang Jiakou, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yichun People\u2019s Hospital, Yichun, Jiangxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"R1-20260707","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/PAS.0b013e31824644ac","article-title":"Malignant gastrointestinal neuroectodermal tumor: Clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of 16 cases with a reappraisal of clear cell sarcoma-like tumors of the gastrointestinal tract","volume":"36","author":"Stockman","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"R3-20260707","doi-asserted-by":"crossref","first-page":"9731","DOI":"10.2147\/OTT.S275633","article-title":"Malignant gastrointestinal neuroectodermal tumors: Clinicopathological and prognostic features of 96 patients","volume":"13","author":"Li","year":"2020","journal-title":"Onco Targets Ther"},{"key":"R4-20260707","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/PAS.0000000000001396","article-title":"Malignant gastrointestinal neuroectodermal tumor: Clinicopathologic, immunohistochemical, and molecular analysis of 19 cases","volume":"44","author":"Chang","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"R5-20260707","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.pathol.2018.05.001","article-title":"Clear cell sarcoma of the gastrointestinal tract and malignant gastrointestinal neuroectodermal tumour: Distinct or related entities? A review","volume":"50","author":"Green","year":"2018","journal-title":"Pathology"},{"key":"R6-20260707","first-page":"831","article-title":"To improve the understanding of CD117-negative gastrointestinal stromal tumor","volume":"22","author":"Zhao","year":"2019","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"R7-20260707","doi-asserted-by":"crossref","first-page":"153663","DOI":"10.1016\/j.prp.2021.153663","article-title":"DOG1 expression is common in human tumors: A tissue microarray study on more than 15,000 tissue samples","volume":"228","author":"Jansen","year":"2021","journal-title":"Pathol Res Pract"},{"key":"R8-20260707","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/1066896915621967","article-title":"DOG1 expression in soft tissue tumors","volume":"24","author":"Ng","year":"2016","journal-title":"Int J Surg Pathol"},{"key":"R9-20260707","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/PAS.0000000000000379","article-title":"Epithelioid malignant peripheral nerve sheath tumor: Clinicopathologic analysis of 63 cases","volume":"39","author":"Jo","year":"2015","journal-title":"Am J Surg Pathol"}],"container-title":["Indian Journal of Pathology and Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijpm.ijpm_9_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:02:29Z","timestamp":1783414949000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/ijpm.ijpm_9_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpm.ijpm_9_25","relation":{},"ISSN":["0377-4929","0974-5130"],"issn-type":[{"value":"0377-4929","type":"print"},{"value":"0974-5130","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-01-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}