{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:33Z","timestamp":1786728513896,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lichen planopilaris is an inflammatory cicatricial alopecia, and its management is a challenge for dermatologists. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate\/week or 200 mg hydroxychloroquine twice a day for 6 months. Side effects, symptoms\/signs, and laboratory tests were assessed periodically. Lichen Planopilaris Activity Index (LPPAI) was measured before intervention and at 2, 4, and 6 months after. The changes from baseline to the end of the study were analyzed within each group and between the two groups by per-protocol and intention-to-treat analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After 2 months, mean (standard deviation [SD]) decrease in LPPAI in methotrexate group was significantly more than that in hydroxychloroquine group (1.68 [1.24] vs. 0.8 [0.71], respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.047). Furthermore, after 6 months, mean (SD) decrease in LPPAI in methotrexate group was significantly higher than that in hydroxychloroquine group (3.3 [2.09] vs. 1.51 [0.91], respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01). The following symptoms\/signs showed significant improvements in frequency and\/or severity in methotrexate group after intervention: pruritus (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007), erythema (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), perifollicular erythema (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), perifollicular scaling (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.08), spreading (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and follicular keratosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). In hydroxychloroquine group, only erythema (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004) showed significant improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Methotrexate was more effective than hydroxychloroquine in treating refractory lichen planopilaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_156_17","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T02:01:26Z","timestamp":1495764086000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["Clinical Efficacy and Safety of Methotrexate versus Hydroxychloroquine in Preventing Lichen Planopilaris Progress: A Randomized Clinical Trial"],"prefix":"10.4103","volume":"8","author":[{"given":"Farahnaz Fatemi","family":"Naeini","sequence":"first","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Saber","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Asilian","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Mohsen","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Epidemiology, School of Public 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