{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:41:50Z","timestamp":1791830510384,"version":"4.3.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n Background:<\/jats:title>\n Tinnitus is the perception of noise or ringing without external acoustic stimulants which affects almost 10% of general population. Many therapies have been recommended including diet modifications, herbal remedies, and chemical drugs. Most common utilized drugs for tinnitus are melatonin and antidepressants such as sertraline which have been proven in different studies. In this study, we aimed to compare the efficacy of melatonin and sertraline in treating tinnitus for the first time.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this clinical trial, 70 patients with tinnitus according to inclusion and exclusion criteria were included and randomly divided into two groups: melatonin group, taking melatonin 3 mg once daily and sertraline group taking sertraline 50 mg once daily, all treating for 3 months. Before and after treatments, every patient received Tinnitus Handicap Inventory (THI) questionnaire and severity of tinnitus was assessed, and data analysis was performed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Before treatments, the mean of THI score for melatonin and sertraline groups were 45.02 \u00b1 17.67 and 44.85 \u00b1 20.57, respectively. There was no significant difference between both groups THI score (\n P<\/jats:italic>\n = 0.23). After 3 months, the mean of THI scores for melatonin and sertraline groups were 30.29 \u00b1 19.62 and 36.96 \u00b1 25.03, respectively which the mean of THI scores in two groups was decreased significantly (\n P<\/jats:italic>\n < 0.01, for-both). In addition, indicated the significant decline in THI score of melatonin group who were under treatments with melatonin 3 mg once daily (\n P<\/jats:italic>\n = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Here in this clinical trial, we demonstrated that both melatonin and sertraline are efficient in treating tinnitus, but the usage of melatonin 3 mg once daily is more effective.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_229_17","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T05:44:48Z","timestamp":1503985488000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of Melatonin and Sertraline Therapies on Tinnitus: A Randomized Clinical Trial"],"prefix":"10.4103","volume":"8","author":[{"given":"Seyed Hamidreza","family":"Abtahi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mostafa","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Nilforoush","sequence":"additional","affiliation":[{"name":"Audiology Department, Communication Disorders Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"issue":"2 Suppl","key":"R1-20250812","first-page":"S1","article-title":"Clinical practice guideline: Tinnitus","volume":"151","author":"Tunkel","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R3-20250812","first-page":"86","article-title":"Treatment of central and sensorineural tinnitus with orally administered melatonin and sulodexide: Personal experience from a randomized controlled study","volume":"29","author":"Neri","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"R4-20250812","doi-asserted-by":"crossref","first-page":"P89","DOI":"10.1016\/j.otohns.2005.05.186","article-title":"The effects of melatonin on tinnitus and sleep","volume":"133","author":"Megwalu","year":"2005","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R5-20250812","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.otohns.2005.07.006","article-title":"Long-term clinical trial of tinnitus retraining therapy","volume":"133","author":"Herraiz","year":"2005","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R6-20250812","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1067\/mhn.2001.114673","article-title":"Chronic tinnitus as phantom auditory pain","volume":"124","author":"Folmer","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R7-20250812","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00005537-199803000-00001","article-title":"Effect of melatonin on tinnitus","volume":"108","author":"Rosenberg","year":"1998","journal-title":"Laryngoscope"},{"key":"R8-20250812","first-page":"523","article-title":"Tinnitus","volume":"8","author":"Waddell","year":"2002","journal-title":"Clin Evid"},{"key":"R9-20250812","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.heares.2006.08.004","article-title":"Antidepressant therapy in tinnitus","volume":"226","author":"Robinson","year":"2007","journal-title":"Hear Res"},{"key":"R10-20250812","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-0447.2000.tb10947.x","article-title":"Anxiety disorders: A review of tricyclic antidepressants and selective serotonin reuptake inhibitors","volume":"403","author":"Zohar","year":"2000","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"R11-20250812","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2273.2001.00490.x","article-title":"British Association of Otolaryngologists. Guidelines for the grading of tinnitus severity: The results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999","volume":"26","author":"McCombe","year":"2001","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"R12-20250812","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1358\/dof.2009.34.5.1362442","article-title":"Pharmacological treatments for tinnitus: New and old","volume":"34","author":"Salvi","year":"2009","journal-title":"Drugs Future"},{"key":"R13-20250812","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2310\/7070.2007.0018","article-title":"Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway","volume":"36","author":"Lopez-Gonzalez","year":"2007","journal-title":"J Otolaryngol"},{"key":"R14-20250812","first-page":"151","article-title":"Drug-mediated ototoxicity and tinnitus: alleviation with melatonin","volume":"62","author":"Reiter","year":"2011","journal-title":"J Physiol Pharmacol"},{"key":"R15-20250812","doi-asserted-by":"crossref","first-page":"362","DOI":"10.14423\/01.SMJ.0000450714.38550.d4","article-title":"Does melatonin have therapeutic use in tinnitus?","volume":"107","author":"Merrick","year":"2014","journal-title":"South Med J"},{"key":"R16-20250812","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.amjoto.2014.06.009","article-title":"Intratympanic dexamethasone plus melatonin versus melatonin only in the treatment of unilateral acute idiopathic tinnitus","volume":"35","author":"Albu","year":"2014","journal-title":"Am J Otolaryngol"},{"key":"R17-20250812","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/01.jcp.0000195111.86650.19","article-title":"The effects of sertraline on severe tinnitus suffering \u2013 a randomized, double-blind, placebo-controlled study","volume":"26","author":"Z\u00f6ger","year":"2006","journal-title":"J Clin Psychopharmacol"},{"key":"R18-20250812","article-title":"Tinnitus guidelines and treatment","volume":"176","author":"Larsen","year":"2014","journal-title":"Ugeskr Laeger"}],"container-title":["International Journal of Preventive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01439446-201708000-00061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:27:24Z","timestamp":1787837244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01439446-201708000-00061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/ijpvm.ijpvm_229_17","relation":{},"ISSN":["2008-7802","2008-8213"],"issn-type":[{"value":"2008-7802","type":"print"},{"value":"2008-8213","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-05-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}