{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:31:21Z","timestamp":1786739481563,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to analyze the effects of vaccination against SARS-CoV-2 on the incidence, lethality and mortality from COVID-19, in the city of S\u00e3o Paulo, in the period 2020-2022. This is a population-based time series study, with official public data, relating to the period from 2020 to 2022. The population data were extracted from the Municipal Health Department of S\u00e3o Paulo, according to the geographic division of the Regional Health Coordination (CRS). The Prais-Winsten regression model was used, calculating the percentage variation of daily change (DPC). This procedure made it possible to classify the trend of epidemiological rates as increasing, decreasing or stationary. It was observed that the city of S\u00e3o Paulo recorded that 17% of its total population was infected at least once by the SARS CoV-2 virus, with a fatal outcome in 0.4% of its total population. When comparing the differences between the CRS, it was observed that the North region had a higher lethality rate at the beginning of the pandemic, decreasing significantly over the period. The Central region, in 2021, showed an increasing trend different from the other regions. Regarding mortality, the North, Center and West coordinators showed decreasing trends in all periods analyzed, unlike the East, Southeast and South coordinators, which in 2020 showed stationary trends. It is concluded that there was a reduction in the epidemiological outcomes of COVID-19 after the mass application of vaccination against SARS-CoV-2. Strategies to increase vaccination coverage should be implemented in all regions of the city of S\u00e3o Paulo, especially in those with high social vulnerability.<\/jats:p>","DOI":"10.4103\/ijpvm.ijpvm_403_24","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:00:44Z","timestamp":1779451244000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Vaccination Against SARS-CoV-2 and its Outcomes on Incidence, Lethality and Mortality from COVID-19 in the City of S\u00e3o Paulo, Brazil"],"prefix":"10.4103","volume":"17","author":[{"given":"Renata M M","family":"Pimentel","sequence":"first","affiliation":[{"name":"Department of Medicine, Municipal University of S\u00e3o Caetano do Sul (USCS). S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Jr.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Medical Residency Program in Family and Community Medicine, Centro Universit\u00e1rio FMABC. Santo Andr\u00e9, Brazil"},{"name":"Laborat\u00f3rio de Ensino, Pesquisa e Tecnologias em Sa\u00fade Caminho de Damasco, S\u00e3o Paulo, 04617-015, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Study Design and Scientific Writing Laboratory, Health Sciences Center, Federal University of Esp\u00edrito Santo, Vit\u00f3ria CEP29043-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edige Felipe","family":"de Sousa Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensino, Pesquisa e Tecnologias em Sa\u00fade Caminho de Damasco, S\u00e3o Paulo, 04617-015, Brazil"},{"name":"Departamento de Epidemiologia, Faculdade de Sa\u00fade P\u00fablica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, CEP01246-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Health, Life Cycles and Society-FSP-USP, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, CEP 01246-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"R10-20260522","doi-asserted-by":"crossref","first-page":"e022033","DOI":"10.9771\/ccrh.v35i0.50271","article-title":"Desigualdades Sociais E Espacialidades Da COVID-19 Em Regi\u00f5es Metropolitanas","volume":"35","author":"B\u00f3gus","year":"2022","journal-title":"Cad CRH"},{"key":"R11-20260522","article-title":"Estimativa dos anos de vida potencialmente perdidos devido ao impacto da Covid-19 no 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