{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:34:34Z","timestamp":1790735674534,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Background:<\/jats:title>\n Migraine is a prevalent health condition associated with significant pain and disability. Neurogenic inflammation has a key role in migraine pathophysiology. Curcumin is a well-known herb compound with anti-inflammatory function. This study was aimed to evaluate the effects of curcumin supplementation on clinical features, as well as on serum levels of calcitonine gene-related peptide (CGRP) and interleukin-6 (IL-6).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This randomized double-blind placebo-controlled clinical trial was carried out on 44 women with migraine, receiving either 500 mg curcumin twice a day or placebo supplements for 8 weeks. Serum CGRP and IL-6 concentration, and clinical symptoms including headache severity, duration and frequency were measured at the baseline and end of study.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n After 8-week intervention, compared with placebo, curcumin supplementation led to significand reduction in CGRP (\n P < 0.001<\/jats:italic>\n ), IL-6 (\n P = 0.041<\/jats:italic>\n ), severity (\n P = 0.001<\/jats:italic>\n ), and duration of headache (\n P = 0.007<\/jats:italic>\n ). Headache frequency showed marginal improvement in curcumin group, compared to controls (\n P = 0.052<\/jats:italic>\n ). Within-analysis indicated significant decrease in CGRP and severity (\n P < 0.001<\/jats:italic>\n ), frequency (\n P = 0.014<\/jats:italic>\n ) and duration (\n P = 0.003<\/jats:italic>\n ) and no significant decrease in IL-6 (\n P = 0.454<\/jats:italic>\n ), compared to baseline in curcumin group. There were no significant changes in body mass index (BMI), weight, percent body fat (PBF), and percent body muscle (PBM) between the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Curcumin supplementation improved the pro-inflammatory markers and clinical features of migraine headaches and that could be contributed to could be to its anti-inflammatory properties.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_405_20","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T08:29:49Z","timestamp":1716884989000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial"],"prefix":"10.4103","volume":"12","author":[{"given":"Sheyda","family":"Rezaie","sequence":"first","affiliation":[{"name":"Department 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