{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:23Z","timestamp":1787070743100,"version":"build-2736575974"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neonatal jaundice is a prevalent disease that causes many complications, including kernicterus and even death. Previous studies have shown that clofibrate as an aryloxy isobutyric acid derivate can be effectively applied for the treatment of neonatal jaundice. Thus, this review was carried out to investigate the effects and mechanism of action of clofibrate on neonatal jaundice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The keywords such as \u201cClofibrate\u201d in combination with \u201cNeonatal jaundice\u201d or \u201cNeonatal hyperbilirubinemia\u201d or \u201cNewborn Jaundice\u201d were used to search for relevant publications indexed in the Institute for Scientific Information (ISI), Scopus, PubMed, and Google Scholar databases. Finally, after reviewing the studies, 24 papers were included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Results showed that the processes of albumin-bound bilirubin transfer to the hepatocytes, hepatic uptake, and storage via ligandin, hepatic conjugation via uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), conjugation into the bile via MRP2 represent the main action mechanism of clofibrate that turns it into the bilirubin conjugates and expels it from the bile. Besides, clofibrate has been shown to reduce the level of Total Serum Bilirubin (TSB) in infants even at a dosage of 25 mg\/kg without leaving side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of this review revealed that clofibrate effectively reduces TSB in short-term usage and can even have a promising effect at the dosage of 25 mg\/kg in full-term infants. Most studies have shown this property over a short period in term infants, and there is no evidence about long-term usage in this regard.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_407_20","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T08:46:23Z","timestamp":1642581983000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["The Effects of Clofibrate on Neonatal Jaundice: A Systematic Review"],"prefix":"10.4103","volume":"13","author":[{"given":"Fathemeh","family":"Eghbalian","sequence":"first","affiliation":[{"name":"Department of Pediatric, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hasanpour-Dehkordi","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Raeisi","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"R1-20250813","first-page":"558","article-title":"Hyperbilirubinemia in neonates: Types, causes, clinical examinations, preventive measures and treatments: A narrative review article","volume":"45","author":"Ullah","year":"2016","journal-title":"Iran J Public Health"},{"key":"R2-20250813","doi-asserted-by":"crossref","first-page":"c2409","DOI":"10.1136\/bmj.c2409","article-title":"Neonatal jaundice: Summary of NICE guidance","volume":"340","author":"Rennie","year":"2010","journal-title":"BMJ"},{"key":"R3-20250813","first-page":"599","article-title":"Hyperbilirubinemia in the term newborn","volume":"65","author":"Porter","year":"2002","journal-title":"Am Fam Phys"},{"key":"R4-20250813","first-page":"8061","article-title":"Risk factors of severe hyperbilirubinemia in neonates undergoing exchange transfusion in Imam Reza Hospital Kermanshah-Iran, during 2012 to 2016","volume":"6","author":"Babaei","year":"2018","journal-title":"Int J Pediatr"},{"key":"R5-20250813","first-page":"163","article-title":"The etiology of severe neonatal hyperbilirubinemia and complications of exchange transfusion","volume":"52","author":"Davutoglu","year":"2010","journal-title":"Turk J Pediatr"},{"key":"R6-20250813","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/diagnostics9010024","article-title":"Clinicopathological spectrum of bilirubin encephalopathy\/kernicterus","volume":"9","author":"Das","year":"2019","journal-title":"Diagnostics (Basel)"},{"key":"R7-20250813","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1089\/bfm.2015.0170","article-title":"Phototherapy for the treatment of neonatal jaundice and breastfeeding duration and exclusivity","volume":"11","author":"Waite","year":"2016","journal-title":"Breastfee Med"},{"key":"R8-20250813","doi-asserted-by":"crossref","first-page":"e20161472","DOI":"10.1542\/peds.2016-1472","article-title":"Neonatal jaundice: Improved quality and cost savings after implementation of a standard pathway","volume":"141","author":"Romero","year":"2018","journal-title":"Pediatrics"},{"key":"R9-20250813","doi-asserted-by":"crossref","first-page":"699","DOI":"10.12968\/hmed.2017.78.12.699","article-title":"Neonatal jaundice: Aetiology, diagnosis and treatment","volume":"78","author":"Mitra","year":"2017","journal-title":"Br J Hosp Med (Lond)"},{"key":"R10-20250813","first-page":"40","article-title":"Outcome of neonatal hyperbilirubinemia in a tertiary care hospital in Bangladesh","volume":"17","author":"Rasul","year":"2010","journal-title":"Malays J Med Sci"},{"key":"R11-20250813","doi-asserted-by":"crossref","first-page":"e000105","DOI":"10.1136\/bmjpo-2017-000105","article-title":"Burden of severe neonatal jaundice: A systematic review and meta-analysis","volume":"1","author":"Slusher","year":"2017","journal-title":"BMJ Paediatr Open"},{"key":"R12-20250813","first-page":"16","article-title":"Management of neonatal jaundice in primary care","volume":"11","author":"Wan","year":"2016","journal-title":"Malays Fam Phys"},{"key":"R13-20250813","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/adc.51.6.454","article-title":"Phototherapy. 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