{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:30:00Z","timestamp":1786739400544,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies indicated the effect of fat on autoimmune diseases. The present study was aimed to investigate the association between fat intake and vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This case\u2013control study was conducted in the Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Intakes of fatty acids were examined for their relation to risk of vitiligo among 100 cases and 110 controls. We included patients who suffered from generalized or localized vitiligo for &lt;5 years that was approved by a dermatologist via the Vitiligo European Task Force criteria and the vitiligo area scoring index. Fat intake was assessed through individual interviews by a standardized food frequency questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Vitiligo group consumed more saturated fatty acid (SFA) and less eicosapentaenoic acid and docosahexaenoic acid than control group, while other fatty acids were not significantly different among two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). Crude analysis showed that total fat (odds ratio [OR] = 3.33, 95% confidence interval [CI]: 1.46\u20137.58) and SFA (OR = 2.22, 95% CI: 1.04\u20134.90) intakes were associated with an increased risk of vitiligo (for highest quartile vs. lowest quartile). Results demonstrated a decrease in the risk of vitiligo for those within the highest quartile of monounsaturated fatty acids intake (OR = 0.41, 95% CI: 0.18\u20130.92). However, this relationship disappeared after adjustment for confounders as energy, age, sex, and body mass index, except for total fat (OR = 2.84, 95% CI: 1.63\u20135.44). Crude and adjusted analyses for polyunsaturated fatty acids and cholesterol intake were not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Total-fat content of the diet had more impressive role than the specific subclasses of fats on the incidence risk of vitiligo. High-fat diet escalated the vitiligo risk. Regarding the role of fats on skin autoimmune diseases especially vitiligo, future studies are crucial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_47_17","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T05:46:45Z","timestamp":1578548805000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Role of Fatty Acids Intake in Generalized Vitiligo"],"prefix":"10.4103","volume":"10","author":[{"given":"Seyedeh-Masomeh","family":"Derakhshandeh-Rishehri","sequence":"first","affiliation":[{"name":"Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahar","family":"Heidari-Beni","sequence":"additional","affiliation":[{"name":"Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Jaffary","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadali","family":"Nilfroshzade","sequence":"additional","affiliation":[{"name":"Skin and Leishmania Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Adibi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"R1-20250812","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4161\/derm.19200","article-title":"When are laboratory tests indicated in patients with vitiligo?","volume":"4","author":"Rodr\u00edguez-Mart\u00edn","year":"2012","journal-title":"Dermatoendocrinol"},{"key":"R4-20250812","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/S0365-05962011000200006","article-title":"Vitiligo epidemiological profile and the association with thyroid disease","volume":"86","author":"Nunes","year":"2011","journal-title":"An Bras Dermatol"},{"key":"R6-20250812","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1590\/S0365-05962009000100006","article-title":"Vitiligo and emotions","volume":"84","author":"Nogueira","year":"2009","journal-title":"An Bras Dermatol"},{"issue":"Suppl","key":"R7-20250812","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.10.001","article-title":"Physiopathology and genetics of vitiligo","volume":"25","author":"Passeron","year":"2005","journal-title":"J Autoimmun"},{"key":"R8-20250812","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1600-0749.2006.00333.x","article-title":"A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo","volume":"19","author":"Dell\u2019anna","year":"2006","journal-title":"Pigment Cell Res"},{"key":"R9-20250812","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1034\/j.1600-0749.2003.00070.x","article-title":"A critical appraisal of vitiligo etiologic theories. 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