{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:45:26Z","timestamp":1790369126673,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Background:<\/jats:title>\n \n The correlation of\n Helicobacter pylori<\/jats:italic>\n infection with gastritis, peptic ulcer, and gastric cancer has been proven. The aim of this study was to determine the effects of\n cagA<\/jats:italic>\n +<\/jats:sup>\n and\n cagA<\/jats:italic>\n \u2212<\/jats:sup>\n genotypes of\n H. pylori<\/jats:italic>\n on genes expression of interleukin (IL) -10 and tumor growth factor (TGF) \u03b21 in gastric epithelial cells of patients with gastritis and\n H. pylori<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In all, 45 gastric biopsy samples were collected from patients with gastritis and\n H. pylori<\/jats:italic>\n infection admitted to Tohid Hospital in Sanandaj city. Status of\n urease<\/jats:italic>\n and\n cagA<\/jats:italic>\n genes of\n H. pylori<\/jats:italic>\n were directly determined from the biopsy samples using polymerase chain reaction (PCR) method. Expression of IL-10 and TGF-\u03b21 genes in gastric epithelial cells of patients with gastritis and\n cagA<\/jats:italic>\n +<\/jats:sup>\n and cagA\n \u2212<\/jats:sup>\n genotypes of\n H. pylori<\/jats:italic>\n infection was serveyed using real-time PCR method.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Overall, 25 samples had infection with\n H. pylori cagA<\/jats:italic>\n +<\/jats:sup>\n and 20 with\n cagA<\/jats:italic>\n \u2212<\/jats:sup>\n genotypes. This study showed that there is a positive correlation between\n cagA<\/jats:italic>\n \u2212<\/jats:sup>\n genotypes of\n H. pylori<\/jats:italic>\n and increasing of IL-10 gene expression in gastric epithelial cells of patients with gastritis (\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Level of gene expression of IL-10 as an anti-inflammatory cytokine in gastric epithelial cells of patients with\n H. pylori<\/jats:italic>\n infection is connected to\n cagA-<\/jats:italic>\n genotypes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_536_18","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T08:42:26Z","timestamp":1716885746000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between Helicobacter pylori cagA Genotypes Infection and IL-10 and TGF\u03b21 Genes' Expression in Gastric Epithelial Cells"],"prefix":"10.4103","volume":"11","author":[{"given":"Saeed","family":"Salavati","sequence":"first","affiliation":[{"name":"Liver and Digestive Research Center, Reaserch Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"},{"name":"Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouchehr","family":"Ahmadi Hedayati","sequence":"additional","affiliation":[{"name":"Liver and Digestive Research Center, Reaserch Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"},{"name":"Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Liver and Digestive Research Center, Reaserch Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"},{"name":"Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Fakhari","sequence":"additional","affiliation":[{"name":"Liver and Digestive Research Center, Reaserch Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"},{"name":"Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Jalili","sequence":"additional","affiliation":[{"name":"Liver and Digestive Research Center, Reaserch Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"},{"name":"Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"R1-20250812","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/2008-7802.177893","article-title":"Meta-analysis of the prevalence of Helicobacter pylori infection among children and adults of Iran","volume":"7","author":"Moosazadeh","year":"2016","journal-title":"Int J Prev Med"},{"key":"R2-20250812","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.3748\/wjg.v20.i19.5610","article-title":"Factors that mediate colonization of the human stomach by Helicobacter pylori","volume":"20","author":"Dunne","year":"2014","journal-title":"World J Gastroenterol"},{"key":"R3-20250812","doi-asserted-by":"crossref","first-page":"91","DOI":"10.13005\/bbra\/2008","article-title":"Prevalence of Hopqalleles and relationship between cagA and vacA S1 with hopQIgene in Helicobacter Pylori strains isolated from patients with peptic ulcer 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