{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:10:25Z","timestamp":1788887425810,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study assesses the impact of vitamin D supplementation on serum cholecalciferol levels and some cytokines in colorectal cancer (CRC) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a thorough search for relevant RCTs in PubMed, Scopus, and Google Scholar using appropriate keywords until December 2024. We calculated weighted mean differences (WMDs) and 95% confidence intervals (CIs) through random-effects analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five studies were included. Combining data from four studies showed a significant increase in serum 25 (OH) cholecalciferol levels after supplementation (WMD: 23.72; 95% CI: 12.92, 34.52). However, results from two studies indicated no significant changes in serum CRP (WMD: -2.48; 95% CI: -7.42, 2.46) and IL-6 (WMD: -2.49; 95% CI: -6.89, 1.92) levels. Conversely, TNF-\u03b1 significantly decreased after administration (WMD: -0.81; 95% CI: -1.18, -0.45). There were no significant changes in anti-inflammatory cytokine IL-10 levels (WMD: 0.29; 95% CI: -0.43, 1.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrates a significant rise in serum 25 (OH) cholecalciferol and a significant decrease in TNF-\u03b1, with no notable changes in serum CRP, IL-6, and IL-10 levels in CRC patients after vitamin D treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijpvm.ijpvm_73_25","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:00:09Z","timestamp":1788249609000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Vitamin D Supplementation on Levels of Serum Cholecalciferol and Cytokines in Individuals with Colorectal Cancer: A Systematic Review and Meta-Analysis of Relevant Clinical Trials"],"prefix":"10.4103","volume":"17","author":[{"given":"Mohamed J.","family":"Saadh","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Middle East University, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Nazar","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technics, College of Health and Medical Technology, Alnoor University, Mosul, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karar H.","family":"Alfarttoosi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ahl Al-Bayt University, Kerbala, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sanghvi","sequence":"additional","affiliation":[{"name":"Marwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roopashree","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Thakur","sequence":"additional","affiliation":[{"name":"Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Department of Nursing, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waam Mohammed","family":"Taher","sequence":"additional","affiliation":[{"name":"College of Nursing, National University of Science and Technology, Dhi Qar, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Alwan","sequence":"additional","affiliation":[{"name":"Pharmacy College, Al-Farahidi University, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood Jasem","family":"Jawad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M. 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