{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:57:50Z","timestamp":1786676270512,"version":"build-2736575974"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":1029,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian Journal of Radiology and Imaging"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective: The aim of our study was to evaluate the diagnostic utility of three-dimensional sampling perfection with application optimized contrast using different flip angle evolution (3D SPACE) sequence and Susceptibility Weighted Imaging (SWI) in hydrocephalus and to propose a refined definition and classification of hydrocephalus with relevance to the selection of treatment option. Materials and Methods: A prospective study of 109 patients with hydrocephalus was performed with magnetic resonance imaging (MRI) brain using standardized institutional sequences along with additional sequences 3D SPACE and SWI. The images were independently read by two senior neuroradiologists and the etiopathogenesis of hydrocephalus was arrived by consensus. Results: With conventional sequences, 46 out of 109 patients of hydrocephalus were diagnosed as obstructive of which 21 patients showed direct signs of obstruction and 25 showed indirect signs. In the remaining 63 patients of communicating hydrocephalus, cause could not be found out in 41 patients. Whereas with 3D SPACE sequence, 88 patients were diagnosed as obstructive hydrocephalus in which all of them showed direct signs of obstruction and 21 patients were diagnosed as communicating hydrocephalus. By including SWI, we found out hemorrhage causing intraventricular obstruction in three patients and hemorrhage at various sites in 24 other patients. With these findings, we have classified the hydrocephalus into communicating and noncommunicating, with latter divided into intraventricular and extraventricular obstruction, which is very well pertaining to the selection of surgical option. Conclusion: We strongly suggest to include 3D SPACE and SWI sequences in the set of routine MRI sequences, as they are powerful diagnostic tools and offer complementary information regarding the precise evaluation of the etiopathogenesis of hydrocephalus and have an effective impact in selecting the mode of management.<\/jats:p>","DOI":"10.4103\/ijri.ijri_161_18","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T10:46:01Z","timestamp":1545302761000},"page":"385-394","source":"Crossref","is-referenced-by-count":6,"title":["Role of 3D SPACE sequence and susceptibility weighted imaging in the evaluation of hydrocephalus and treatment-oriented refined classification of hydrocephalus"],"prefix":"10.1055","volume":"28","author":[{"given":"Amarnath","family":"Chellathurai","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Govt Stanley Medical College, Affiliated to The Tamil Nadu Dr. MGR Medical University, Anna Salai, Guindy, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komalavalli","family":"Subbiah","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Govt Stanley Medical College, Affiliated to The Tamil Nadu Dr. MGR Medical University, Anna Salai, Guindy, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barakath Nisha Abdul","family":"Ajis","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Govt Stanley Medical College, Affiliated to The Tamil Nadu Dr. MGR Medical University, Anna Salai, Guindy, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhasini","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Govt Stanley Medical College, Affiliated to The Tamil Nadu Dr. MGR Medical University, Anna Salai, Guindy, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathyan","family":"Gnanasigamani","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Govt Stanley Medical College, Affiliated to The Tamil Nadu Dr. MGR Medical University, Anna Salai, Guindy, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"ref1","volume-title":"Hydrocephalus","author":"M A Fishman","year":"1978"},{"key":"ref2","volume-title":"Hydrocephalus: Etiology, pathologic effects, diagnosis, and natural history","author":"C M Carey","year":"1994","edition":"3rd ed"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/archpedi.1914.02180010416002","article-title":"Internal hydrocephalus. An experimental, clinical and pathological study","volume":"8","author":"W E Dandy","year":"1914","journal-title":"Am J Dis Child"},{"key":"ref4","first-page":"112","volume-title":"Observation on the pathology of hydrocephalus. Medical Research Council. Special report series No. 265","author":"D S Russell","year":"1949"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/bmj.d4191","article-title":"Contemporary management and recent advances in paediatric hydrocephalus","volume":"343","author":"J Kandasamy","year":"2011","journal-title":"BMJ"},{"key":"ref6","first-page":"185","article-title":"New concepts in the pathogenesis of hydrocephalus","volume":"3","author":"S Krishnamurthy","year":"2014","journal-title":"Translat Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10143-004-0326-9","article-title":"Radiological assessment of hydrocephalus: New theories and implications for therapy","volume":"27","author":"D Greitz","year":"2004","journal-title":"Neurosurg Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s13244-014-0333-5","article-title":"Evaluation of hydrocephalus and other cerebrospinal fluid disorders with MRI: An update","volume":"5","author":"M G Kartal","year":"2014","journal-title":"Insights Imaging"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3174\/ajnr.A1726","article-title":"Is all \u201cCommunicating\u201d hydrocephalus really communicating? Prospective study on the value of 3D-constructive interference in steady state sequence at 3T","volume":"30","author":"A Din\u00e7er","year":"2009","journal-title":"Am J Neuroradiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3174\/ajnr.A2833","article-title":"Evaluation of aqueductal stenosis by three-dimensional sampling perfection with application optimized contrasts using different flip-angle evolutions (3D-SPACE) sequence: Preliminary results with 3 Tesla MRI","volume":"33","author":"O Algin","year":"2012","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"20160834","DOI":"10.1259\/bjr.20160834","article-title":"Comparison of post-contrast 3D-T1-MPRAGE, 3D-T1-SPACE and 3D-T2-FLAIR MR images in evaluation of meningeal abnormalities at 3-T MRI","volume":"90","author":"B Jeevanandham","year":"2017","journal-title":"Br J Radiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/0971-3026.29034","article-title":"SWI, a new MRI sequence-how useful it is?","volume":"16","author":"S B Desai","year":"2006","journal-title":"Indian J Radiol Imaging"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3174\/ajnr.A1400","article-title":"Susceptibility-weighted imaging: Technical aspects and clinical applications, part 1","volume":"30","author":"E M Haacke","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1590\/0100-3984.2014.0010","article-title":"Susceptibility weighted imaging: Differentiating between calcification and hemosiderin","volume":"48","author":"J H Barbosa","year":"2015","journal-title":"Radiol Bras"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11604-014-0385-y","article-title":"Diagnostic performance of heavily T2-weighted techniques in obstructive hydrocephalus: Comparison study of two different 3D heavily T2-weighted and conventional T2-weighted sequences","volume":"33","author":"M Ucar","year":"2015","journal-title":"Japn J Radiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00234-007-0316-z","article-title":"Clinical applications of susceptibility weighted MR imaging of the brain \u2014 a pictorial review","volume":"50","author":"B Thomas","year":"2008","journal-title":"Neuroradiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13760-017-0838-z","article-title":"Evaluation of hydrocephalus patients with 3D-SPACE technique using variant FA mode at 3T","volume":"118","author":"O Algin","year":"2018","journal-title":"Acta Neurol Belg"},{"key":"ref18","first-page":"1527","article-title":"Detection of intracranial hemorrhage with susceptibility-weighted MR sequences","volume":"20","author":"L Liang","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"044","DOI":"10.1055\/s-0036-1572367","article-title":"Susceptibility weighted imaging: A novel method to determine the etiology of aqueduct stenosis","volume":"05","author":"C Chavadi","year":"2016","journal-title":"IJNS"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/neurosurgery\/46.1.104","article-title":"How effective is endoscopic third ventriculostomy in treating adult hydrocephalus caused by primary aqueductal stenosis?","volume":"46","author":"M Tisell","year":"2000","journal-title":"Neurosurgery"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00270903","article-title":"Choroid plexectomy for the treatment of chronic infected hydrocephalus","volume":"4","author":"C Lapras","year":"1988","journal-title":"Childs Nerv Syst"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s003810050186","article-title":"Late 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