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Magnetic resonance imaging (MRI) of the brain showed extensive bilateral optic nerve inflammation with post-contrast gadolinium enhancement on T1-weighted sequence. The involvement was limited to the anterior segments of the optic nerves sparing chiasma and optic tracts. Anti-aquaporin-4 antibody (AQP4) was negative while anti-myelin oligodendrocyte glycoprotein antibody (MOG) was positive. After intravenous methylprednisolone, his vision dramatically improved. The patient was discharged with only mildly impaired visual acuity, 2 weeks after admission. Follow-up brain MRI and MOG assay after 3 months were within normal limits.<\/jats:p>","DOI":"10.4103\/ijri.ijri_486_19","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T03:09:20Z","timestamp":1594868960000},"page":"222-224","source":"Crossref","is-referenced-by-count":2,"title":["Anti-myelin oligodendrocyte glycoprotein antibody-positive coursing with optic neuritis: Imaging and clinical implications"],"prefix":"10.1055","volume":"30","author":[{"given":"Nithisha","family":"Thatikonda","sequence":"additional","affiliation":[{"name":"Medical Student, GMC Nagpur, MUHS, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gomez","sequence":"additional","affiliation":[{"name":"Radiology Research Fellow, Louisiana State University Health Science Centre, Shreveport, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Gonazalez","family":"Toledo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Louisiana State University Health Science Centre, Shreveport, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1007\/s00415-018-9122-2","article-title":"Neurological update: MOG antibody disease","volume":"266","author":"R Wynford-Thomas","year":"2019","journal-title":"J Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/1971400917698856","article-title":"Anti-myelin oligodendrocyte glycoprotein antibodies: Magnetic resonance imaging findings in a case series and a literature review","volume":"31","author":"M Cellina","year":"2018","journal-title":"Neuroradiol J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neurad.2019.06.001","article-title":"MRI features of demyelinating disease associated with anti-MOG antibodies in adults","volume":"46","author":"M Den\u00e8ve","year":"2019","journal-title":"J Neuroradiol"},{"key":"ref4","first-page":"1","article-title":"Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis","volume":"15","author":"S Ramanathan","year":"2015","journal-title":"Mult Scler"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00415-017-8615-8","article-title":"Optic neuritis in patients with anti-MOG antibodies spectrum disorder: MRI and clinical features from a large multicentric cohort in France","volume":"264","author":"D Biotti","year":"2017","journal-title":"J Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"A Compston","year":"2008","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1212\/WNL.0000000000000101","article-title":"Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders","volume":"82","author":"D K Sato","year":"2014","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jnnp-2014-310206","article-title":"MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: A comparative study","volume":"87","author":"T Akaishi","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neurad.2018.10.007","article-title":"Optic chiasm and oculomotor nerves involvement in active multiple sclerosis","volume":"47","author":"C Carra-Dalliere","year":"2020","journal-title":"J Neuroradiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajo.2018.07.020","article-title":"Myelin oligodendrocyte glycoprotein antibody-positive optic neuritis: Clinical characteristics, radiologic clues, and outcome","volume":"195","author":"J J Chen","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-016-0718-0","article-title":"MOG-IgG in NMO and related disorders: A multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome","volume":"13","author":"S Jarius","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1212\/NXI.0000000000000163","article-title":"Antibodies to MOG in adults with inflammatory demyelinating disease of the CNS","volume":"2","author":"S M Kim","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"}],"container-title":["Indian Journal of Radiology and Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/ijri.IJRI_486_19.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T20:07:47Z","timestamp":1626725267000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/ijri.IJRI_486_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":12,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,7,19]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.4103\/ijri.ijri_486_19","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-3026","1998-3808"],"issn-type":[{"value":"0971-3026","type":"print"},{"value":"1998-3808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}