{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:51:37Z","timestamp":1790959897863,"version":"4.1.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":383,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian Journal of Radiology and Imaging"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Context and Aims: Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm with intermediate malignant potential. The aim of this study is to describe and compare the clinical presentation, computed tomography (CT) findings and anaplastic lymphoma kinase -1 (ALK-1) expression of IMT of the thorax in children and adults. We also sought to study the tumour behaviour after treatment on the follow-up imaging. Materials and Method: This is a retrospective observational study of 22 histopathologically proven cases of IMT in the thorax. The clinical parameters, CT findings, biopsy results, treatment received and follow-up were recorded. Statistical analysis was performed using Fisher\u2019s exact test. Results: IMT of the thorax had diverse imaging appearances, presenting either as large invasive lung masses with or without calcifications or as smaller endobronchial lesions. Children commonly presented with long duration fever (P = 0.02) and large invasive lung masses (P = 0.026), whereas adults presented with long duration haemoptysis (P = 0.001) and endobronchial lesions or smaller lung parenchymal lesions. Calcifications were more common in children (P = 0.007). ALK-1 was positive in 40% of children and 18.2% of adults (P = 0.547). Endobronchial lesions showed a trend for ALK-1 negativity. Patients with bronchoscopic excision had local recurrence and patients with surgical wedge resection had metastatic brain lesions as compared to those with lobectomy and pneumonectomy (P = 0.0152). A patient with unresectable lung mass had malignant transformation to spindle cell sarcoma after 9.5 years. Conclusions: Thoracic IMT presents with some distinct clinical and CT findings in adults and children. The CT findings and management options have implications for prognosis. If resectable, lobectomy is a better option than wedge resection or bronchoscopic excision for preventing local recurrence and metastasis. IMT can undergo malignant transformation.<\/jats:p>","DOI":"10.4103\/ijri.ijri_93_20","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T14:45:10Z","timestamp":1603464310000},"page":"266-272","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory myofibroblastic tumours of the thorax: Radiologic and clinicopathological correlation"],"prefix":"10.1055","volume":"30","author":[{"given":"Aparna","family":"Irodi","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita R","family":"Chacko","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India"},{"name":"Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena R","family":"Vimala","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasahayam J","family":"Christopher","sequence":"additional","affiliation":[{"name":"Departments of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birla R","family":"Gnanamuthu","sequence":"additional","affiliation":[{"name":"Departments of Thoracic Surgery, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.21037\/jtd.2017.02.89","article-title":"Pulmonary inflammatory myofibroblastic tumor versus IgG4- related inflammatory pseudotumor: Differential diagnosis based on a case series","volume":"9","author":"L Zhu","year":"2017","journal-title":"J Thorac Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2214\/AJR.15.14494","article-title":"CT manifestations of inflammatory myofibroblastic tumors (inflammatory pseudotumors) of the urinary system","volume":"206","author":"W Liang","year":"2016","journal-title":"AJR Am J 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Siminovich","year":"2012","journal-title":"Pediatr Dev Pathol"},{"key":"ref18","first-page":"908","article-title":"Inflammatory myofibroblastic tumour of the lung: A reactive lesion or a true neoplasm?","volume":"7","author":"N Panagiotopoulos","year":"2015","journal-title":"J Thorac Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/1450-1147.136739","article-title":"Inflammatory myofibroblastic tumor of the lung: Unusual imaging findings","volume":"12","author":"K Pavithran","year":"2013","journal-title":"World J Nucl Med"},{"key":"ref20","first-page":"e1183","article-title":"Synchronous inflammatory myofibroblastic tumor in lung and brain: A case report and review of literature","volume":"9","author":"M Jehangir","year":"2017","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/PAS.0b013e318200cfd5","article-title":"Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal 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