{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:06Z","timestamp":1787762046613,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Syphilis is caused by a spirochete,\n                      <jats:italic toggle=\"yes\">Treponema pallidum<\/jats:italic>\n                      . Diagnosis of syphilis is made with a venereal disease research laboratory test. Treatment of choice is intramuscular injection benzathine Penicillin. The Jarisch[FIGURE DASH]Herxheimer reaction (JHR) is a transient immunological phenomenon that can occur in patients during treatment for syphilis with penicillin. It is a rare phenomenon but can be a potentially severe one. It manifests clinically with short-term constitutional symptoms such as fever, chills, headache, and myalgia, besides exacerbation of existing cutaneous lesions. We report the case of a 24-year-old man presenting with JHR posttreatment with benzathine penicillin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijstd.ijstd_107_22","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T03:01:40Z","timestamp":1685934100000},"page":"79-81","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Jarisch[FIGURE DASH]Herxheimer reaction"],"prefix":"10.4103","volume":"44","author":[{"given":"Manjyot","family":"Gautam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin J.","family":"Nadkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240831","first-page":"721","article-title":"Therapeutic attempts in syphilis","volume":"45","author":"Jarisch","year":"1895","journal-title":"Wien Med Wochenschrift"},{"key":"R2-19-20240831","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1055\/s-0028-1139096","article-title":"About one occurring in syphilitic mercury reaction","volume":"28","author":"Herxheimer","year":"1902","journal-title":"German Med Wochenschr"},{"key":"R4-19-20240831","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0361-1124(76)80309-7","article-title":"Jarisch-Herxheimer reaction. Case report","volume":"5","author":"Meislin","year":"1976","journal-title":"JACEP"},{"key":"R5-19-20240831","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2710.2005.00631.x","article-title":"Proposed mechanisms and preventative options of Jarisch-Herxheimer reactions","volume":"30","author":"Pound","year":"2005","journal-title":"J Clin Pharm Ther"},{"key":"R6-19-20240831","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1468-3083.2012.04544.x","article-title":"Jarisch-Herxheimer reaction among syphilis patients in China","volume":"27","author":"Li","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R7-19-20240831","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1054\/jocn.2002.1129","article-title":"A case of neurosyphilis with a florid Jarisch-Herxheimer reaction","volume":"9","author":"Silberstein","year":"2002","journal-title":"J Clin Neurosci"}],"container-title":["Indian Journal of Sexually Transmitted Diseases and AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijstd.ijstd_107_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:11:07Z","timestamp":1787760667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijstd.ijstd_107_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijstd.ijstd_107_22","relation":{},"ISSN":["2589-0557"],"issn-type":[{"value":"2589-0557","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}