{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:31:22Z","timestamp":1787070682571,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Candidial balanitis, balanoposthitis and vulvovaginitis can be diagnosed by direct microscopy, culture and treated with antifungals. Resistance to antifungals is emerging. Hence, we conducted a study to identify the causative species and antifungal susceptibility.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To observe the species differentiation and antifungal susceptibility pattern in patients with genital candidiasis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A prospective observational study was carried out that included 54 patients of age group (18-60 years) diagnosed clinically and direct microscopically (KOH) for genital candidiasis. Culture was done using Sabouraud dextrose agar. Species identification and antifungal susceptibility were tested. Descriptive data were expressed in the form of frequency and percentage.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Out of 54 patients, 41 had culture positive candidiasis. Among the isolated species, 68.3% were\n Candida albicans<\/jats:italic>\n (28\/41) and 31.7% were non\n - albicans Candida spp<\/jats:italic>\n . Among non-\n albicans Candida<\/jats:italic>\n species (13\/41),\n Candida glabrata<\/jats:italic>\n (19.5%),\n Candida tropicalis<\/jats:italic>\n (7.3%),\n Candida guilliermondii<\/jats:italic>\n (2.4%),\n Candida parapsilosis<\/jats:italic>\n (2.4%) were identified. Antifungal susceptibility was tested for fluconazole (FLU), clotrimazole (CLTZ), itraconazole (ITZ), ketoconazole (KTZ), voriconazole (VOR), amphotericin-B (AMPH-B). Except\n C. glabrata<\/jats:italic>\n and\n C.parapsilosis<\/jats:italic>\n , all other species were sensitive to all tested antifungals. All isolated species were sensitive to KTZ, VOR, AMPH-B, and CLTZ. Nearly 22% of isolates were resistant to fluconazole.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n C. glabrata<\/jats:italic>\n causes complicated, severe recurrent vulvovaginitis which is fluconazole resistant. Drug sensitivity prior prescribing antifungal agent identifies appropriate drug, decreases patient\u2019s disease morbidity and cross resistance.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijstd.ijstd_58_23","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T08:11:35Z","timestamp":1717661495000},"page":"11-14","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A prospective observational study on species differentiation and antifungal susceptibility pattern in patients with genital candidiasis"],"prefix":"10.4103","volume":"45","author":[{"given":"S.","family":"Sivagamasundari","sequence":"first","affiliation":[{"name":"Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriramajayam","family":"Lavanya","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"R1-20240831","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1128\/JCM.38.3.1063-1065.2000","article-title":"Evaluation of the Oricult-N dipslide for laboratory diagnosis of vaginal candidiasis","volume":"38","author":"Carlson","year":"2000","journal-title":"J Clin Microbiol"},{"key":"R2-20240831","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.12.1.80","article-title":"Candida glabrata:Review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans","volume":"12","author":"Fidel","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"R3-20240831","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7241\/ourd.20201.1","article-title":"Candida balanitis. 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