{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:31Z","timestamp":1786649311345,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    Alopecia is usually an overlooked manifestation of syphilis commonly seen in secondary syphilis with a prevalence of 2.9%\u20137%. It is broadly classified into symptomatic and essential alopecia and the observed patterns include moth-eaten type, generalized thinning, and mixed pattern. Here, we report a 38-year-old male who presented with mixed pattern alopecia of the scalp and bilateral postauricular lymphadenopathy. Toluidine red unheated serum test and\n                    <jats:italic toggle=\"yes\">Treponema pallidum<\/jats:italic>\n                    hemagglutination were positive in a titer of 1:128 and 1:720, respectively. Trichoscopy showed empty follicles, perifollicular and interfollicular scales, faint reddish-brown pigmentation, black dots, and broken and regrowing hairs. The patient was treated with a single dose of benzathine penicillin 2.4 million IU intramuscular injection. The patient was regularly followed up and showed marked regrowth of hairs and resolution of postauricular lymphadenopathy. Lymph node and hair examination and trichoscopy as a noninvasive tool could aid in the diagnosis of alopecia syphilitica.\n                  <\/jats:p>","DOI":"10.4103\/ijstd.ijstd_60_24","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T07:04:47Z","timestamp":1734073487000},"page":"144-147","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Moth-eaten alopecia and beyond: Syphilitic alopecia - Revisited"],"prefix":"10.4103","volume":"45","author":[{"given":"Aravind Baskar","family":"Murthy","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, SRM Medical College Hospital and Research Center, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayasankar","family":"Palaniappan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragul Raj","family":"Elango","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaliaperumal","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000477415","article-title":"Syphilitic alopecia: Case reports and trichoscopic findings","volume":"3","author":"Doche","year":"2017","journal-title":"Skin Appendage Disord"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/0190-9622(95)91543-5","article-title":"Essential syphilitic alopecia revisited","volume":"32","author":"Cuozzo","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"R3-20260424","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1525-1470.2006.00310.x","article-title":"Early diffuse alopecia in a neonate with congenital syphilis","volume":"23","author":"Reddy","year":"2006","journal-title":"Pediatr Dermatol"},{"key":"R4-20260424","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00000372-199504000-00008","article-title":"The moth-eaten alopecia of secondary syphilis. A histopathological study of 12 patients","volume":"17","author":"Jordaan","year":"1995","journal-title":"Am J Dermatopathol"},{"key":"R5-20260424","doi-asserted-by":"crossref","first-page":"890206","DOI":"10.3389\/fmed.2022.890206","article-title":"Epidemiological, clinical, and trichoscopic features of syphilitic alopecia: A retrospective analysis and systematic review","volume":"9","author":"Pomsoong","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"R6-20260424","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/archderm.1926.02370160032003","article-title":"Syphilitic alopecia: Its relation to neurosyphilis","volume":"13","author":"Wile","year":"1926","journal-title":"Arch Dermatol Syphilol"},{"key":"R7-20260424","first-page":"548","article-title":"Secondary syphilis presenting with \u201ccrown of Venus\u201d alopecia","volume":"35","author":"Cavazos","year":"2022","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"R8-20260424","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000431314","article-title":"Hair and scalp manifestations in secondary syphilis: Epidemiology, clinical features and trichoscopy","volume":"231","author":"Piraccini","year":"2015","journal-title":"Dermatology"},{"key":"R9-20260424","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archderm.1965.01600070100027","article-title":"Eyebrow alopecia: The omnibus sign","volume":"91","author":"Arnold","year":"1965","journal-title":"Arch Dermatol"},{"key":"R10-20260424","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.ajo.2022.07.004","article-title":"Syphilitic uveitis and alopecia","volume":"242","author":"Fowler","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"R11-20260424","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1111\/1346-8138.15405","article-title":"Mixed-pattern syphilitic alopecia of the scalp associated with uveitis and asymptomatic neurosyphilis","volume":"47","author":"Al-Busani","year":"2020","journal-title":"J Dermatol"},{"key":"R12-20260424","first-page":"e21901","article-title":"Frontal fibrosing alopecia mimicking alopecia syphilitica","volume":"14","author":"Diehl","year":"2022","journal-title":"Cureus"},{"key":"R13-20260424","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5826\/dpc.0703a12","article-title":"Syphilitic alopecia: Uncommon trichoscopic findings","volume":"7","author":"Tognetti","year":"2017","journal-title":"Dermatol Pract Concept"},{"key":"R14-20260424","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0560.1991.tb00133.x","article-title":"Alopecia syphilitica, a simulator of alopecia areata: Histopathology and differential diagnosis","volume":"18","author":"Lee","year":"1991","journal-title":"J Cutan Pathol"},{"issue":"Suppl 1","key":"R15-20260424","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0560.2006.00726.x","article-title":"Alopecia syphilitica with detection of Treponema pallidum in the hair follicle","volume":"34","author":"Nam-Cha","year":"2007","journal-title":"J Cutan Pathol"},{"key":"R16-20260424","first-page":"361","article-title":"Alopecia in association with sexually transmitted disease: A review","volume":"76","author":"Vafaie","year":"2005","journal-title":"Cutis"}],"container-title":["Indian Journal of Sexually Transmitted Diseases and AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijstd.ijstd_60_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:15Z","timestamp":1786647135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijstd.ijstd_60_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijstd.ijstd_60_24","relation":{},"ISSN":["2589-0557","2589-0565"],"issn-type":[{"value":"2589-0557","type":"print"},{"value":"2589-0565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-05-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}