{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:49:51Z","timestamp":1787071791194,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with syphilis, who receive appropriate treatment, fail to achieve serological cure and have persistent nontreponemal titers. This study was conducted to analyze the factors associated with serofast stage after the treatment of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective study was conducted from January 2019 to June 2022, involving 70 patients with syphilis who were followed up for 12 months using the Venereal Disease Research Laboratory (VDRL) test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Primary syphilis was observed in 11.4% (8), secondary syphilis in 77.2% (54), and latent syphilis in 11.4% (8) of the patients. The serological cure rates at 3, 6, 9, and 12 months were 10% (7\/70), 41.4% (29\/70), 50% (35), and 62.8% (44), respectively. Patients &lt;25 years and with higher baseline VDRL titers (&gt;1:16) had a better response to treatment. HIV-positive patients had 1.7-fold higher odds of serological failure compared to HIV-negative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In conclusion, our study underscores the need for tailored approaches to syphilis management and highlights the importance of ongoing research to enhance our understanding of treatment response predictors and optimize patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijstd.ijstd_66_24","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T10:00:19Z","timestamp":1765360819000},"page":"155-158","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of serological cure and serofast stage after treatment in patients with syphilis: A retrospective study from India"],"prefix":"10.4103","volume":"46","author":[{"given":"Sunil","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, PGIMER, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimjhim","family":"Kanaujia","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, PGIMER, Lucknow, India"},{"name":"Department of Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugan","family":"Sankaranantham","sequence":"additional","affiliation":[{"name":"SHIFA Hospitals, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, PGIMER, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karamjit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, PGIMER, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, PGIMER, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"R1-20251210","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(16)32411-4","article-title":"Syphilis","volume":"389","author":"Hook","year":"2017","journal-title":"Lancet"},{"key":"R2-20251210","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1111\/j.1755-5949.2010.00183.x","article-title":"REVIEW: Neurosyphilis: A historical perspective and review","volume":"16","author":"Ghanem","year":"2010","journal-title":"CNS Neurosci Ther"},{"key":"R5-20251210","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s12879-015-1209-0","article-title":"Asystematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: Rethinking the significance of serological non-responsiveness and the serofast state after therapy","volume":"15","author":"Se\u00f1a","year":"2015","journal-title":"BMC Infect Dis"},{"key":"R6-20251210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1056\/NEJM199707313370504","article-title":"Arandomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. 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