{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:15Z","timestamp":1787071335205,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The most frequent pediatric dermatophyte infection globally is tinea capitis (TC). Hair follicles have a variety of immunological defense mechanisms to stop infections from entering it. Natural-killer group 2, member D receptor ligands include unique long binding protein 3 (ULBP3) has a significant impact on the regulation of immunological reactions that are innate and adaptive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate the serum level of ULBP3 in patients with TC, its clinical significance, relation to types of dermatophytes, disease severity, and pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>There were 60 TC patients and 30 normal subjects in this case\u2013control study. A culture of hair samples was done on Sabouraud dextrose agar with cycloheximide to know the type of dermatophyte, and the serum level of ULBP3 was done using ELIZA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      TC patients reported substantially higher plasma ULBP3 concentrations than healthy controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). ULBP3 showed a clear overall difference between organisms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). It was noticeably greater in\n                      <jats:italic toggle=\"yes\">Trichophyton verrucosum<\/jats:italic>\n                      compared to other organisms. A substantial positive correlation between the Clinical Severity Score and the ULBP3 was observed (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.434 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Serum ULBP3 might be involved in TC pathogenesis. Moreover, ULBP3 serum level could be considered a standalone risk predictor for TC susceptibility, activity, and severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_104_24","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:06:25Z","timestamp":1763654785000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Can Serum UL16 Binding Protein 3 Tell Us More about Tinea Capitis?"],"prefix":"10.4103","volume":"17","author":[{"given":"Doaa M.","family":"Elhabak","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mennat Allah A.","family":"Ghazala","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menha Abd El-Fatah","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"El-Fallaha","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany Kasem","family":"Shahat","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha 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