{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:56:04Z","timestamp":1791665764866,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Syndromes, defined as clusters of consistent symptoms, are vital in understanding diseases and disorders. The interplay between hair and clinical syndromes is examined in brief here, emphasizing the need for a unified data resource to aid clinicians and postgraduate students. The syndromes are categorized into hypertrichosis, characterized by excessive hair growth, and hypotrichosis, defined by a lack of hair. For hypertrichosis, various syndromes such as Ambras, Cant\u00fa, and Rubinstein-Taybi syndrome are elucidated, highlighting their distinct clinical features and genetic underpinnings. Hypotrichosis syndromes include Bjornstad\u2019s, Netherton and Rothmund-Thomson syndromes. By categorizing and elucidating the array of hair-related syndromes, this comprehensive review aims to enhance clinical understanding and improve patient care in this domain.<\/jats:p>","DOI":"10.4103\/ijt.ijt_107_23","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T15:00:12Z","timestamp":1750690812000},"page":"4-12","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Syndromes Associated with Hair Disorders"],"prefix":"10.4103","volume":"17","author":[{"given":"Mauli M.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shree","family":"Dhanani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragya A.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"R1-20250628","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0974-7753.188036","article-title":"Ambras syndrome with gingival hyperplasia:A rare entity","volume":"8","author":"Reddy Kundoor","year":"2016","journal-title":"Int J Trichology"},{"key":"R2-20250628","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/ccr3.1014","article-title":"Barber-say syndrome:A confirmed case of TWIST2 gene mutation","volume":"5","author":"Yohannan","year":"2017","journal-title":"Clin Case Rep"},{"key":"R3-20250628","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13052-015-0161-3","article-title":"Congenital generalized hypertrichosis:The skin as a clue to complex malformation syndromes","volume":"41","author":"Pavone","year":"2015","journal-title":"Ital J Pediatr"},{"key":"R6-20250628","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cge.12499","article-title":"Cornelia de Lange syndrome","volume":"88","author":"Boyle","year":"2015","journal-title":"Clin Genet"},{"key":"R8-20250628","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/jama.1976.03260400024021","article-title":"Fetal alcohol syndrome. Experience with 41 patients","volume":"235","author":"Hanson","year":"1976","journal-title":"JAMA"},{"key":"R9-20250628","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-3476(75)80604-4","article-title":"The fetal hydantoin syndrome","volume":"87","author":"Hanson","year":"1975","journal-title":"J Pediatr"},{"key":"R10-20250628","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/ejcts\/ezaa108","article-title":"Is Gorlin-Chaudhry-Moss syndrome associated with aortopathy?","volume":"58","author":"Legu\u00e9","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"key":"R11-20250628","doi-asserted-by":"crossref","first-page":"857","DOI":"10.4103\/jfmpc.jfmpc_1435_21","article-title":"Review of the current literature on H syndrome treatment","volume":"11","author":"Saleh Anaraki","year":"2022","journal-title":"J Family Med Prim Care"},{"key":"R12-20250628","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/0974-7753.142873","article-title":"Marie-unna hereditary hypotrichosis","volume":"6","author":"Srinivas","year":"2014","journal-title":"Int J Trichology"},{"key":"R13-20250628","doi-asserted-by":"crossref","first-page":"e231749","DOI":"10.1136\/bcr-2019-231749","article-title":"Hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome):An extreme subphenotype of polycystic ovary syndrome","volume":"13","author":"O'Brien","year":"2020","journal-title":"BMJ Case Rep"},{"key":"R15-20250628","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ccr3.465","article-title":"Hypertrichosis cubiti, a case report and literature review","volume":"4","author":"Tng","year":"2016","journal-title":"Clin Case Rep"},{"key":"R16-20250628","doi-asserted-by":"crossref","first-page":"437","DOI":"10.18203\/2349-3291.ijcp20200125","article-title":"Acquired generalized lipodystrophy type 2-lawrence syndrome:A rare case report","volume":"7","author":"Dhanalakshmi","year":"2020","journal-title":"Int J Contemp Pediatr"},{"key":"R17-20250628","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/13816810.2021.1904419","article-title":"Oliver McFarlane syndrome:Two new cases and a review of the literature","volume":"42","author":"Lisbjerg","year":"2021","journal-title":"Ophthalmic Genetics"},{"key":"R18-20250628","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jaad.2020.01.075","article-title":"Polycystic ovary syndrome in patients with hair thinning","volume":"83","author":"Prasad","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"R19-20250628","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.blre.2007.07.004","article-title":"POEMS syndrome","volume":"21","author":"Dispenzieri","year":"2007","journal-title":"Blood Rev"},{"key":"R20-20250628","doi-asserted-by":"crossref","first-page":"30","DOI":"10.11604\/pamj.2017.26.30.11525","article-title":"Schinzel-Giedion syndrome:A case with sacrococcygeal teratoma and cor-triatriatum dexter","volume":"26","author":"Anyanwu","year":"2017","journal-title":"Pan Afr Med J"},{"key":"R21-20250628","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1001\/archderm.144.10.1351","article-title":"The stiff skin syndrome:Case series, differential diagnosis of the stiff skin phenotype, and review of the literature","volume":"144","author":"Liu","year":"2008","journal-title":"Arch Dermatol"},{"key":"R22-20250628","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13256-018-1704-1","article-title":"A rare case of seven siblings with Waardenburg syndrome:a case report","volume":"12","author":"Haj Kassem","year":"2018","journal-title":"Journal of medical case reports"},{"key":"R23-20250628","doi-asserted-by":"crossref","first-page":"e452","DOI":"10.4317\/jced.55214","article-title":"Zimmermann-Laband syndrome:Clinical and cytogenetic study in two related patients","volume":"11","author":"Shirian","year":"2019","journal-title":"J Clin Exp Dent"},{"key":"R25-20250628","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4103\/ijdvl.IJDVL_599_17","article-title":"Bazex-Dupr\u00e9-Christol syndrome:First report in an Indian family","volume":"84","author":"Chauhan","year":"2018","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R27-20250628","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/0974-7753.179400","article-title":"Carvajal syndrome","volume":"8","author":"Srinivas","year":"2016","journal-title":"Intern J Trichol"},{"key":"R28-20250628","first-page":"1","article-title":"Ectodermal dysplasias","author":"Grange","year":"2013","journal-title":"InEmery and Rimoin's Principles and Practice of Medical Genetics:Elsevier"},{"key":"R30-20250628","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2340\/00015555-0337","article-title":"Conradi-H\u00fcnermann-Happle syndrome (X-linked dominant chondrodysplasia punctata) confirmed by plasma sterol and mutation analysis","volume":"88","author":"Kolb-M\u00e4urer","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"R31-20250628","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s13555-019-0313-2","article-title":"Genetic hair disorders:A review","volume":"9","author":"Ahmed","year":"2019","journal-title":"Dermatol Ther (Heidelb)"},{"key":"R32-20250628","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000457898","article-title":"A case report of Cushing's disease presenting as hair loss","volume":"9","author":"Lefkowitz","year":"2017","journal-title":"Case Rep Dermatol"},{"key":"R33-20250628","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0974-7753.82129","article-title":"Graham-little Piccardi Lassueur syndrome:An unusual variant of follicular lichen planus","volume":"3","author":"Pai","year":"2011","journal-title":"Int J Trichology"},{"key":"R34-20250628","doi-asserted-by":"crossref","first-page":"965560","DOI":"10.3389\/fdmed.2022.965560","article-title":"Hallermann-Streiff syndrome:Case report with abnormal pulp calcifications","volume":"3","author":"Ammar","year":"2022","journal-title":"Front Dent Med"},{"key":"R35-20250628","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4103\/0974-7753.77513","article-title":"Loose anagen hair syndrome","volume":"2","author":"Dhurat","year":"2010","journal-title":"Int J Trichology"},{"key":"R38-20250628","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/0378-6323.38410","article-title":"Naxos disease:A rare occurrence of cardiomyopathy with woolly hair and palmoplantar keratoderma","volume":"74","author":"Rai","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R40-20250628","first-page":"45","article-title":"Roberts-SC Phocomelia syndrome (Pseudothalidomide syndrome):A case report","volume":"7","author":"Keypour","year":"2013","journal-title":"J Family Reprod Health"},{"key":"R41-20250628","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/idoj.IDOJ_100_16","article-title":"Rapp Hodgkin syndrome","volume":"8","author":"Chatterjee","year":"2017","journal-title":"Indian Dermatol Online J"},{"key":"R42-20250628","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1172-5-2","article-title":"Rothmund-Thomson syndrome","volume":"5","author":"Larizza","year":"2010","journal-title":"Orphanet J Rare Dis"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_107_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:14Z","timestamp":1787067314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_107_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_107_23","relation":{},"ISSN":["0974-7753","0974-9241"],"issn-type":[{"value":"0974-7753","type":"print"},{"value":"0974-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2023-10-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}