{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:16Z","timestamp":1791389476434,"version":"4.3.3"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alopecia totalis (AT) is an autoimmune condition and severe form of alopecia areata characterized by complete scalp hair loss, often posing treatment challenges, especially in pediatric patients. This case report presents a 7-year-old boy with a 2-year history of alopecia, who developed AT. The patient initially showed limited response to a combination of Wysolone (prednisolone) and methotrexate. The introduction of topical tofacitinib along with mometasone resulted in significant hair regrowth and improvement in hair density over a 4-month period. This case highlights the potential of topical Janus kinase inhibitors as a promising treatment for the pediatric patient with AT.<\/jats:p>","DOI":"10.4103\/ijt.ijt_108_24","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:01:37Z","timestamp":1763654497000},"page":"248-250","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Use of Topical Tofacitinib in Pediatric Alopecia Totalis"],"prefix":"10.4103","volume":"17","author":[{"given":"Sahil","family":"Sardana","sequence":"first","affiliation":[{"name":"Deparment of Dermatology, Sewak Sabha Hospital (Charitable Trust), Hisar, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"R1-20251121","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"R2-20251121","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4103\/0019-5154.103066","article-title":"Current treatment strategies in pediatric alopecia areata","volume":"57","author":"Wang","year":"2012","journal-title":"Indian J Dermatol"},{"key":"R3-20251121","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/ajd.14325","article-title":"Real-world effectiveness and safety of tofacitinib for alopecia areata:A retrospective cohort study of 202 patients","volume":"65","author":"Cranwell","year":"2024","journal-title":"Australas J Dermatol"},{"key":"R4-20251121","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaad.2016.09.006","article-title":"Tofacitinib for the treatment of alopecia areata and variants in adolescents","volume":"76","author":"Craiglow","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"R5-20251121","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.jid.2018.01.032","article-title":"An open-label pilot study to evaluate the efficacy of tofacitinib in moderate to severe patch-type alopecia areata, totalis, and universalis","volume":"138","author":"Jabbari","year":"2018","journal-title":"J Invest Dermatol"},{"key":"R6-20251121","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jaad.2016.09.007","article-title":"Tofacitinib for the treatment of severe alopecia areata and variants:A study of 90 patients","volume":"76","author":"Liu","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"R7-20251121","first-page":"59","article-title":"Alopecia areata \u2013Current understanding and management","volume":"20","author":"Lintzeri","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"R8-20251121","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/ijt.ijt_15_22","article-title":"Recovery of resistant alopecia areata treated with tofacitinib:An 8-year-old child's case report","volume":"14","author":"Bhokare","year":"2022","journal-title":"Int J Trichology"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_108_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:27Z","timestamp":1787067867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_108_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_108_24","relation":{},"ISSN":["0974-7753","0974-9241"],"issn-type":[{"value":"0974-7753","type":"print"},{"value":"0974-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-11-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}