{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:22:45Z","timestamp":1787764965426,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Folliculitis decalvans (FD) represents a chronic and recurrent pustulofollicular scalp inflammation resulting in scarring alopecia. The presence of a bacterial bioflilm at the interface of the hair shaft may provide an explanation for the chronicity and high relapse rate of FD, even after prolonged systemic antibiotic treatments. We originally read with enthusiasm Meli\u00e1n-Olivera\n                    <jats:italic toggle=\"yes\">et al<\/jats:italic>\n                    .\u2019s retrospective study of patients with FD treated with topical dapsone published in the\n                    <jats:italic toggle=\"yes\">Journal of the American Academy of Dermatology<\/jats:italic>\n                    . However, we experienced an unsuccessful trial of 5% dapsone gel in a patient with FD resulting in worsening of the disease with a pustular flareup and questioned why positive study reports with novel therapeutic options in dermatology often fail in practice. The authors admitted the limitations of their study: small sample size, retrospective, uncontrolled nature of the study, and concomitant use of other treatments. Clinical research ultimately aims at improving the patient outcome. For this purpose, trials must evaluate the outcomes that genuinely reflect the clinical utility of drugs. Therefore, we postulate stricter criteria for treatment trials and statistics in dermatology before publication in peer-reviewed scientific journals to avoid frustrations of physicians and patients alike.\n                  <\/jats:p>","DOI":"10.4103\/ijt.ijt_39_22","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T07:00:09Z","timestamp":1701673209000},"page":"88-90","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Comment on Topical Dapsone for Folliculitis Decalvans"],"prefix":"10.4103","volume":"15","author":[{"given":"Ralph Michel","family":"Tr\u00fceb","sequence":"first","affiliation":[{"name":"Center for Dermatology and Hair Diseases Professor Tr\u00fceb, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc-Nhi Catharina","family":"Luu","sequence":"additional","affiliation":[{"name":"Center for Dermatology and Hair Diseases Professor Tr\u00fceb, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hudson Dutra","family":"Rezende","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lusiada University Center, Santos, S\u00e3o Paulo-Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"R1-20240903","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1468-3083.2012.04591.x","article-title":"First evidence of bacterial biofilms in the anaerobe part of scalp hair follicles:A pilot comparative study in folliculitis decalvans","volume":"27","author":"Matard","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R2-20240903","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaad.2021.07.004","article-title":"Topical dapsone for folliculitis decalvans:A retrospective cohort study","volume":"87","author":"Meli\u00e1n-Olivera","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"R3-20240903","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2133.1993.tb00476.x","article-title":"Dapsone:Modes of action, toxicity and possible strategies for increasing patient tolerance","volume":"129","author":"Coleman","year":"1993","journal-title":"Br J Dermatol"},{"key":"R4-20240903","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/ced.13989","article-title":"Folliculitis decalvans and lichen planopilaris phenotypic spectrum:A case series of biphasic clinical presentation and theories on pathogenesis","volume":"45","author":"Yip","year":"2020","journal-title":"Clin Exp Dermatol"},{"key":"R5-20240903","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jamadermatol.2018.1175","article-title":"Dynamic trichoscopy","volume":"154","author":"Tr\u00fceb","year":"2018","journal-title":"JAMA Dermatol"},{"key":"R6-20240903","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010814-124614","article-title":"How good is \u201cevidence\u201dfrom clinical studies of drug effects and why might such evidence fail in the prediction of the clinical utility of drugs?","volume":"55","author":"Naci","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R7-20240903","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13063-017-1870-2","article-title":"Why clinical trial outcomes fail to translate into benefits for patients","volume":"18","author":"Heneghan","year":"2017","journal-title":"Trials"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_39_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:52:46Z","timestamp":1787763166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_39_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_39_22","relation":{},"ISSN":["0974-7753","0974-9241"],"issn-type":[{"value":"0974-7753","type":"print"},{"value":"0974-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-04-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}