{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:00Z","timestamp":1787169660279,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is an autoimmune disease characterized by peribulbar lymphocytic infiltration, follicular miniaturization, catagen\/telogen follicles, and increased follicular stelae (streamers) in skin biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our aim was to assess the number of follicular stelae of patients with AA and to evaluate their association with clinical type and severity and treatment response of AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Histopathologic features including number of follicular stelae were recorded in skin biopsies taken from lesions of AA in 142 patients who attended our dermatology clinic from 2011 to 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was a statistically significant correlation between the patient age and the number of follicular stelae (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). There was a statistically significant correlation between the severity of disease and the number of follicular stelae (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005). AA subtypes (0%\u201325% scalp hair loss) had a significantly lower number of follicular stelae than 75%\u2013100% scalp hair loss and alopecia universalis (7.92 \u00b1 4.21 vs. 13.23 \u00b1 7.28). There was no statistically significant correlation between the treatment response and the number of follicular stelae (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results showed that number of follicular stelae varied among AA clinical types and correlated with severity. This study was the first to evaluate the correlation between the number of follicular stelae and severity of AA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_48_19","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:30:23Z","timestamp":1678689023000},"page":"204-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Association between the Number of Follicular Stelae and Severity and Treatment Response of Alopecia Areata Cases"],"prefix":"10.4103","volume":"14","author":[{"given":"G\u00fcll\u00fc","family":"Gencebay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"A\u015fk\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6vg\u00fc","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Server","family":"Serdaro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240903","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"R2-3-20240903","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2017.04.1141","article-title":"Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis","volume":"78","author":"Strazzulla","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"R3-3-20240903","first-page":"191","article-title":"Epidemiologic and genetic characteristics of alopecia areata (part 1)","volume":"20","author":"Alzolibani","year":"2011","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"R4-3-20240903","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1001\/archderm.139.12.1555","article-title":"Histopathologic features of alopecia areata: A newlook","volume":"139","author":"Whiting","year":"2003","journal-title":"Arch Dermatol"},{"key":"R5-3-20240903","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jaad.2011.02.017","article-title":"Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates","volume":"65","author":"Peckham","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"R6-3-20240903","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/j.1600-0560.2008.00987.x","article-title":"Follicular streamers (stelae) in scarring and non-scarring alopecia","volume":"35","author":"Horenstein","year":"2008","journal-title":"J Cutan Pathol"},{"key":"R7-3-20240903","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/DAD.0000000000000973","article-title":"Elastic staining in differentiating between follicular streamers and follicular scars in horizontal scalp biopsy sections","volume":"40","author":"Tan","year":"2018","journal-title":"Am J Dermatopathol"},{"key":"R8-3-20240903","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00000372-200606000-00051","article-title":"Histopathologic evaluation of alopecias","volume":"28","author":"Sellheyer","year":"2006","journal-title":"Am J Dermatopathol"},{"key":"R9-3-20240903","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0190-9622(97)70219-6","article-title":"Eosinophils in fibrous tracts and near hair bulbs: A helpful diagnostic feature of alopecia areata","volume":"37","author":"Elston","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"R10-3-20240903","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1001\/jamadermatol.2014.62","article-title":"Diagnostic usefulness of a peribulbar eosinophilic infiltrate in alopecia areata","volume":"150","author":"Yoon","year":"2014","journal-title":"JAMA Dermatol"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_48_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:09:30Z","timestamp":1787166570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_48_19"}},"subtitle":["A Retrospective Study"],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_48_19","relation":{},"ISSN":["0974-7753"],"issn-type":[{"value":"0974-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}