{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:52:07Z","timestamp":1788875527120,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Platelet-rich plasma (PRP) therapy is a new method for the treatment of androgenetic alopecia (AGA), the effectiveness and safety of which continues to be studied. Information on comparative efficacy when combining PRP with other methods of treatment is limited. The aim of the study was a comparative evaluation of the clinical efficacy of minoxidil, PRP therapy, and their combination in the treatment of men with AGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study included 69 men. The patients were divided into three observation groups: the main group (25 people, received applications of a 5% solution of minoxidil in combination with PRP injections), the comparison group (22 people, received intradermal injections of PRP), and the control group (22 people, received applications of a 5% solution of minoxidil). The clinical efficacy of the therapy was evaluated by the dynamics of morphometric indicators of hair growth using a digital camera and the software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      It was established that after complex therapy in the form of minoxidil applications and injections of PRP, the hair density increased by 32% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00004), the diameter of the hair shafts by 26% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00004), the share of vellus hair decreased by 30% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00082), and the proportion of telogen hair decreased by 39% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.00008). The results of using complex therapy significantly exceeded the clinical effect of platelet-rich plasma and topical applications of a 5% solution of minoxidil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The data obtained allows suggesting that PRP and minoxidil potentiate each other's action when used together and their complex application seems promising for the treatment of androgenetic alopecia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_50_19","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T01:44:32Z","timestamp":1643766272000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Combination therapy with platelet-rich plasma and minoxidil leads to better clinical results than monotherapy with these methods in men with androgenetic alopecia"],"prefix":"10.4103","volume":"14","author":[{"given":"E Pakhomova","family":"Elena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O Smirnova","family":"Irina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20240903","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2133.2010.10011.x","article-title":"S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents","volume":"164","author":"Blume-Peytavi","year":"2011","journal-title":"Br J Dermatol"},{"key":"R2-1-20240903","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1087-0024.2005.10102.x","article-title":"Prevalence of male and female pattern hair loss in Maryborough","volume":"10","author":"Gan","year":"2005","journal-title":"J Investig Dermatol Symp Proc"},{"key":"R4-1-20240903","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00238-013-0816-5","article-title":"Platelet-rich plasma injection is effective and safe for the treatment of alopecia","volume":"36","author":"Betsi","year":"2013","journal-title":"Eur J Plast Surg"},{"key":"R6-1-20240903","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0974-2077.150743","article-title":"Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period","volume":"7","author":"Gkini","year":"2014","journal-title":"J Cutan Aesthet Surg"},{"key":"R7-1-20240903","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0974-2077.138352","article-title":"Platelet-rich plasma in androgenic alopecia: Myth or an effective tool","volume":"7","author":"Khatu","year":"2014","journal-title":"J Cutan Aesthet Surg"},{"key":"R8-1-20240903","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1111\/dsu.12037","article-title":"Letter: Platelet-rich plasma for treating male pattern baldness","volume":"38","author":"Park","year":"2012","journal-title":"Dermatol Surg"},{"key":"R9-1-20240903","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1055\/s-0034-1371896","article-title":"Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia","volume":"30","author":"Sclafani","year":"2014","journal-title":"Facial Plast Surg"},{"key":"R10-1-20240903","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/jdv.14624","article-title":"Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men \u2013 Short version","volume":"32","author":"Kanti","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R11-1-20240903","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/DSS.0000000000001198","article-title":"Platelet-rich plasma in combination with 5% minoxidil topical solution and 1 mg oral finasteride for the treatment of androgenetic alopecia: A randomized placebo-controlled, double-blind, half-head study","volume":"44","author":"Alves","year":"2018","journal-title":"Dermatol Surg"},{"key":"R12-1-20240903","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00238-015-1175-1","article-title":"Management of androgenetic alopecia: A comparative clinical study between plasma rich in growth factors and topical minoxidil","volume":"39","author":"Navarro","year":"2016","journal-title":"Eur J Plast Surg"},{"key":"R13-1-20240903","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/ijt.ijt_64_18","article-title":"A study to compare the efficacy of platelet-rich plasma and minoxidil therapy for the treatment of androgenetic alopecia","volume":"11","author":"Verma","year":"2019","journal-title":"Int J Trichology"},{"key":"R14-1-20240903","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/ijt.ijt_75_16","article-title":"A comparative study of microneedling with platelet-rich plasma plus topical minoxidil (5%) and topical minoxidil (5%) alone in androgenetic alopecia","volume":"9","author":"Shah","year":"2017","journal-title":"Int J Trichology"},{"key":"R15-1-20240903","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/jid.2012.24","article-title":"Dickkopf 1 promotes regression of hair follicles","volume":"132","author":"Kwack","year":"2012","journal-title":"J Invest Dermatol"},{"key":"R16-1-20240903","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/PRS.0b013e3182450ac9","article-title":"Subcutaneous injections of platelet-rich plasma into skin flaps modulate proangiogenic gene expression and improve survival rates","volume":"129","author":"Li","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"R17-1-20240903","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1524-4725.2012.02394.x","article-title":"Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth","volume":"38","author":"Li","year":"2012","journal-title":"Dermatol Surg"},{"key":"R18-1-20240903","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/09546630903578574","article-title":"Hair growth and rejuvenation: An overview","volume":"22","author":"Semalty","year":"2011","journal-title":"J Dermatolog Treat"},{"key":"R19-1-20240903","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0009-8981(87)90322-6","article-title":"Sulfation of minoxidil by human platelet sulfotransferase","volume":"169","author":"Johnson","year":"1987","journal-title":"Clin Chim Acta"},{"key":"R20-1-20240903","doi-asserted-by":"crossref","first-page":"317","DOI":"10.21103\/Article8(4)_OA9","article-title":"Morphological substantiation of clinical efficacy of platelet rich plasma in the treatment of androgenetic alopecia","volume":"8","author":"Pakhomova","year":"2018","journal-title":"Int J Biomed"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_50_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:08:22Z","timestamp":1787166502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_50_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_50_19","relation":{},"ISSN":["0974-7753"],"issn-type":[{"value":"0974-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}