{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:22:45Z","timestamp":1787764965282,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Androgenetic alopecia leads to progressive hair loss in susceptible individuals if left untreated. Topical minoxidil represents an evidence-based treatment for female androgenetic alopecia, though with variable success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>Treatment of minoxidil non-responders remains challenging, as does treatment of patients with propylene glycol sensitivity or irritable scalp syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Single-center, retrospective cohort of 50 female patients with androgenetic alopecia failing to respond to a minimum of 6 months of standard 5% topical minoxidil solution either once daily or b.i.d. depending on the severity of the alopecia. Patients were switched to propylene glycol-free, North American Witch Hazel (Hamamelis virginiana)-based solution of 5% minoxidil sulfate (5% minoxidil sensitive solution). Efficacy and safety of treatment were evaluated, including stereotactic global photography and epiluminiscence microscopy with digital imaging taken at baseline, at 3, and at 6 months of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>70% of patients showed observable clinical improvement with combined global photographic and epiluminiscence microscopic assessment with digital imaging, and 22% epiluminiscence microscopic-only improvement as evidence of treatment efficacy. The treatment was well tolerated, particularly in patients with propylene glycol sensitivity and patients with irritable scalp syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These results suggest that propylene glycol-free, North American witch hazel (\n                      <jats:italic toggle=\"yes\">Hamamelis virginiana<\/jats:italic>\n                      )-based solution of 5% minoxidil is effective and safe for treatment of female androgenetic alopecia, specifically in minoxidil non-responders and patients with propylene glycol sensitivity or irritable scalp syndrome.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_55_22","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T07:00:16Z","timestamp":1701673216000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel (Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia"],"prefix":"10.4103","volume":"15","author":[{"given":"Ralph Michel","family":"Tr\u00fceb","sequence":"first","affiliation":[{"name":"Center for Dermatology and Hair Diseases Professor Tr\u00fceb, Zurich-Wallisellen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"R1-20240903","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000228319","article-title":"Red scalp disease \u2013 A rosacea-like dermatosis of the scalp?Successful therapy with oral tetracycline","volume":"219","author":"Oberholzer","year":"2009","journal-title":"Dermatology"},{"key":"R2-20240903","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000074111","article-title":"Is androgenetic alopecia a photoaggravated dermatosis?","volume":"207","author":"Tr\u00fceb","year":"2003","journal-title":"Dermatology"},{"key":"R3-20240903","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/sj.jid.5701147","article-title":"Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression","volume":"128","author":"Bahta","year":"2008","journal-title":"J Invest Dermatol"},{"key":"R4-20240903","article-title":"Successful Treatment of Androgenetic Alopecia Refractory to Topical 5% Minoxidil b.i.d. with 10% Minoxidil Sulphate Solution Once Daily. 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