{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:20Z","timestamp":1787071340031,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Oral minoxidil (OM) is approved by the US Food and Drug Administration for the treatment of hypertension. It has also been off-label used increasingly for hair disorders like androgenetic alopecia (AGA). Hypertrichosis is known as the most commonly found adverse effect of oral minoxidil (LDOM) at low dose of 0.25\u20135 mg. This study aims to describe the characteristics of hypertrichosis induced by 5 mg daily oral low-dose minoxidil for 24 weeks in male AGA treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This prospective study included 30 male AGA patients who received treatment with 5 mg daily oral low-dose minoxidil. The modified Ferriman\u2013Gallwey scoring system was used for the assessment of hypertrichosis by physicians in the forearm area at baseline, 12 and 24 weeks. The Dermatology Life Quality Index was applied to assess the impact of hypertrichosis on quality of life. Patients were divided into two age groups: under 41 and 41 or older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Hypertrichosis was prevalent in 93% of patients, especially the younger group with a higher incidence and variation of severity. Most patients indicated a general tolerance with minimal impact on their quality of life. Notably, hypertrichosis seldom led to drug discontinuation despite a widespread occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The 24-week treatment of low-dose 5 mg daily OM induces a high prevalence of hypertrichosis in male AGA patients. Further study is recommended for long-term implications and safety profiles of low-dose oral minoxidil.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijt.ijt_55_24","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:09:18Z","timestamp":1763654958000},"page":"215-220","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of Hypertrichosis Induced by 24-week Low-dose (5 mg Daily) Oral Minoxidil in Male Pattern Hair Loss Treatment"],"prefix":"10.4103","volume":"17","author":[{"given":"Suparuj","family":"Lueangarun","sequence":"first","affiliation":[{"name":"Department of Aesthetic Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand"},{"name":"Division of Dermatology, DeMed Clinic Center, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratchathorn","family":"Panchaprateep","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therdpong","family":"Tempark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"R1-20251121","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaad.2020.06.1009","article-title":"Oral minoxidil treatment for hair loss:A review of efficacy and safety","volume":"84","author":"Randolph","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"R2-20251121","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.jaad.2023.05.004","article-title":"Medical and procedural treatment of androgenetic alopecia \u2013Where are we?","volume":"89","author":"Ly","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"R3-20251121","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s13555-020-00448-x","article-title":"Efficacy and safety of oral minoxidil 5 mg once daily in the treatment of male patients with androgenetic alopecia:An open-label and global photographic assessment","volume":"10","author":"Panchaprateep","year":"2020","journal-title":"Dermatol Ther (Heidelb)"},{"key":"R4-20251121","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/ijt.ijt_53_20","article-title":"Pili trianguli et canaliculi:A case report with 10-year follow-up","volume":"14","author":"Lueangarun","year":"2022","journal-title":"Int J Trichology"},{"key":"R5-20251121","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1210\/jcem-21-11-1440","article-title":"Clinical assessment of body hair growth in women","volume":"21","author":"Ferriman","year":"1961","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-20251121","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4103\/0378-6323.86481","article-title":"Dermatology life quality index in Thai patients with systemic sclerosis:A cross-sectional study","volume":"77","author":"Chularojanamontri","year":"2011","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R7-20251121","first-page":"150","article-title":"Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss","volume":"13","author":"Whiting","year":"2003","journal-title":"Eur J Dermatol"},{"key":"R8-20251121","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2230.2012.04376.x","article-title":"Pseudofolliculitis barbae induced by oral minoxidil","volume":"37","author":"Liew","year":"2012","journal-title":"Clin Exp Dermatol"},{"key":"R9-20251121","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/ijd.13838","article-title":"Female pattern hair loss:A pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone","volume":"57","author":"Sinclair","year":"2018","journal-title":"Int J Dermatol"},{"key":"R10-20251121","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2133.2004.05785.x","article-title":"Minoxidil:Mechanisms of action on hair growth","volume":"150","author":"Messenger","year":"2004","journal-title":"Br J Dermatol"},{"key":"R11-20251121","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jaad.2020.08.124","article-title":"Characterization and management of hypertrichosis induced by low-dose oral minoxidil in the treatment of hair loss","volume":"84","author":"Jimenez-Cauhe","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"R12-20251121","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/dth.12111","article-title":"Novel enzymatic assay predicts minoxidil response in the treatment of androgenetic alopecia","volume":"27","author":"Goren","year":"2014","journal-title":"Dermatol Ther"},{"key":"R13-20251121","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0738-081X(88)90086-7","article-title":"Histologic response to topically applied minoxidil in male-pattern alopecia","volume":"6","author":"Abell","year":"1988","journal-title":"Clin Dermatol"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_55_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:38Z","timestamp":1787067878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijt.ijt_55_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijt.ijt_55_24","relation":{},"ISSN":["0974-7753","0974-9241"],"issn-type":[{"value":"0974-7753","type":"print"},{"value":"0974-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-05-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}